A halogenated ether with anesthetic properties
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Sevoflurane

Item No. 23996

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-propane
CAS Number
28523-86-6
Synonyms
  • Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl ester
  • Fluoromethyl 1,1,1,3,3,3-Hexafluoro-2-propyl ester
Molecular Formula
C4H3F7O
Formula Weight
200.1
Purity
≥95%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: miscibleDMSO: miscibleEthanol: misciblePBS (pH 7.2): miscible
SMILES
FCOC(C(F)(F)F)C(F)(F)F
InChi Code
InChI=1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2
InChi Key
DFEYYRMXOJXZRJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 g

    $75

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    10 g

    $143

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    25 g

    $333

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    50 g

    $627

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    Product Description

    Sevoflurane is a halogenated ether with anesthetic properties.1 It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively).2 Sevoflurane (360 µM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an α1β2γ2 subunit composition.3 It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM).4 Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Campagna, J.A., Miller, K.W., Phil, D., et al. Mechanisms of actions of inhaled anesthetics. N. Engl. J. Med. 348(21), 2110-2124 (2003).

    2. Krasowski, M.D., and Harrison, N.L. The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Br. J. Pharmacol. 129(4), 731-743 (2000).

    3. Nishikawa, K., and Harrison, N.L. The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: Effects of TM2 mutations in the alpha and beta subunits. Anesthesiology 99(3), 678-684 (2003).

    4. Rada, E.M., Tharakan, E.C., and Flood, P. Volatile anesthetics reduce agonist affinity at nicotinic acetylcholine receptors in the brain. Anesth. Analg. 96(1), 108-111 (2003).