A polyamine chelating agent
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Product Type

Biochemicals
Metal Chelators

Research Area

Neuroscience

Trientine (hydrochloride)

Item No. 24000

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N2-bis(2-aminoethyl)-1,2-ethanediamine, dihydrochloride
CAS Number
38260-01-4
Synonyms
  • Triethylenetetramine
Molecular Formula
C6H18N4 • 2HCl
Formula Weight
219.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Slightly Soluble
SMILES
NCCNCCNCCN.Cl.Cl
InChi Code
InChI=1S/C6H18N4.2ClH/c7-1-3-9-5-6-10-4-2-8;;/h9-10H,1-8H2;2*1H
InChi Key
WYHIICXRPHEJKI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $49

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    500 mg

    $93

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    1 g

    $171

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    Product Description

    Trientine is a polyamine chelating agent.1 It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride.2 Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sarkar, B., Sass-Kortsak, A., Clarke, R., et al. A comparative study of in vitro and in vivo interaction of D-penicillamine and triethylenetetramine with copper. Proc. R. Soc. Med. 70(Suppl 3), 13-18 (1977).

    2. Behari, J.R. Use of liposome entrapped triethylenetetramine (TETA) in the treatment of mice loaded with nickel chloride. Ind. Health 25(4), 221-224 (1987).