A prodrug form of methyldopa
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Active Metabolite(s)
21814L-(−)-α-Methyldopa
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Methyldopate

Item No. 24002

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-α-methyl-L-tyrosine, ethyl ester
CAS Number
6014-30-8
Synonyms
  • α-Methyldopa ethyl ester
Molecular Formula
C12H17NO4
Formula Weight
239.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
OC1=C(O)C=CC(C[C@](C)(N)C(OCC)=O)=C1
InChi Code
InChI=1S/C12H17NO4/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8/h4-6,14-15H,3,7,13H2,1-2H3/t12-/m0/s1
InChi Key
SVEBYYWCXTVYCR-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    Product Description

    Methyldopate is an ethyl ester prodrug form of methyldopa (Item No. 21814), a dopamine decarboxylase inhibitor that has antihypertensive activity in vitro and in vivo.1,2,3,4 Formulations containing methyldopate have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, B., Bobek, G., Makris, A., et al. Antihypertensive methyldopa, labetalol, hydralazine, and clonidine reversed tumour necrosis factor-α inhibited endothelial nitric oxide synthase expression in endothelial-trophoblast cellular networks. Clin. Exp. Pharmacol. Physiol. 44(3), 421-427 (2016).

    2. Onesti, G., Brest, A.N., Novack, P., et al. Pharmacodyamic effects of alpha-methyl dopa in hypertensive subjects. Am. Heart J. 67(1), 32-38 (1964).

    3. LeDoux, J.E., Sakaguchi, A., and Reis, D.J. Alpha-methylDOPA dissociates hypertension, cardiovascular reactivity and emotional behavior in spontaneously hypertensive rats. Brain Res. 259(1), 69-76 (1983).

    4. Vlase, L., Mihu, D., Popa, D.-S., et al. Determination of methyldopa in human plasma by LC/MS-MS for therapeutic drug monitoring. Studia UBB Chemia 57(1), 31-41 (2013).