A mast cell stabilizer
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Nedocromil (sodium salt)

Item No. 24005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, disodium salt
CAS Number
69049-74-7
Molecular Formula
C19H15NO7 • 2Na
Formula Weight
415.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
251, 286, 339, 372 nm
SMILES
O=C(C=C(C([O-])=O)O1)C(C1=C2CCC)=CC3=C2N(CC)C(C([O-])=O)=CC3=O.[Na+].[Na+]
InChi Code
InChI=1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2
InChi Key
JQEKDNLKIVGXAU-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Nedocromil is a mast cell stabilizer.1 It inhibits IgE-induced histamine release from rat peritoneal mast cells cocultured with 3T3 cells (MC/3T3) and preincubated with IL-2 when used at a concentration of 10 µM in acute (1 hour) and chronic (5 days) assays. Nedocromil prevents early- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin.2 It also prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis when administered intravenously at a dose of 2 mg/kg.3 Formulations containing nedocromil have been used in the treatment of allergic conjunctivitis and asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rubinchik, E., Norris, A., and Levi-Schaffer, F. Modulations of histamine release from mast cells by interleukin-2 is affected by nedocromil sodium. Int. J. Immunopharmacol. 17(7), 563-570 (1995).

    2. Hutson, P.A., Holgate, S.T., and Church, M.K. Inhibition by nedocromil sodium of early and late phase bronchoconstriction and airway cellular infiltration provoked by ovalbumin inhalation in conscious sensitized guinea-pigs. Br. J. Pharmacol. 94(1), 6-8 (1988).

    3. McGrath, L.E., Doherty, M.J., Easty, D.L., et al. Nedocromil sodium in two models of conjunctival immediate hypersensitivity. Adv. Ther. 17(1), 7-13 (2000).