An anticonvulsant
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Seizure Disorders

Ethotoin

Item No. 24022

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-ethyl-5-phenyl-2,4-imidazolidinedione
CAS Number
86-35-1
Synonyms
  • (±)-Ethotoin
Molecular Formula
C11H12N2O2
Formula Weight
204.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=C(C(C1=CC=CC=C1)N2)N(CC)C2=O
InChi Code
InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
InChi Key
SZQIFWWUIBRPBZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $69

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    10 mg

    $120

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    25 mg

    $248

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    Product Description

    Ethotoin is a hydantoin anticonvulsant.1,2 It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg.2 It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the duration of the clonic phase at any dose.2 Ethotoin (20 mg/kg, i.p.) decreases serum cholesterol and triglyceride concentrations in mice to 67 and 60%, respectively, of control after 16 days of treatment.3 Formulations containing ethotoin have been used in the treatment of tonic-clonic and complex partial seizures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Livingston, S. The use of peganone (AC 695) in the treatment of epilepsy. J. Pediatr. 49(6), 728-732 (1956).

    2. Kamei, C., Masuda, Y., Oka, M., et al. Effects of antiepileptics on both behavioral and electrographic seizure patterns induced by maximal electroshock in rats. Epilepsia 19(6), 625-636 (1978).

    3. Maguire, J.H., Murthy, A.R., and Hall, I.H. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice. Eur. J. Pharmacol. 117(1), 135-138 (1985).