A non-nucleoside reverse transcriptase inhibitor
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Delavirdine (mesylate)

Item No. 24026

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-methanesulfonamide, monomethanesulfonate
CAS Number
147221-93-0
Molecular Formula
C22H28N6O3S • CH3SO3H
Formula Weight
552.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/mlEthanol: 10 mg/ml
λmax
224, 303 nm
SMILES
CC(C)NC1=CC=CN=C1N2CCN(C(C3=CC4=C(C=CC(NS(C)(=O)=O)=C4)N3)=O)CC2.O=S(O)(C)=O
InChi Code
InChI=1S/C22H28N6O3S.CH4O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-5(2,3)4/h4-8,13-15,24-26H,9-12H2,1-3H3;1H3,(H,2,3,4)
InChi Key
MEPNHSOMXMALDZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).1 It inhibits growth of clinical isolates of HIV-1 (ED50s = <0.005-0.69 μM). Delavirdine blocks replication of 25 primary HIV-1 isolates, including strains resistant to 3'-azido-2',3'-deoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean ED50 value of 0.066 μM. Delavirdine also inhibits growth of L. infantum promastigotes (IC50 = 26.1 μM).2 Formulations containing delavirdine have been used in the treatment of HIV.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dueweke, T.J., Poppe, S.M., Romero, D.L., et al. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agents Chemother. 37(5), 1127-1131 (1993).

    2. Costa, S., Machado, M., Cavadas, C., et al. Antileishmanial activity of antiretroviral drugs combined with miltefosine. Parasitol Res. 115(10), 3881-3887 (2016).