An AChE inhibitor
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Echothiophate (iodide)

Item No. 24029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-ethanaminium, monoiodide
CAS Number
513-10-0
Molecular Formula
C9H23NO3PS • I
Formula Weight
383.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly SolubleWater: Slightly Soluble
SMILES
C[N+](C)(C)CCSP(OCC)(OCC)=O.[I-]
InChi Code
InChI=1S/C9H23NO3PS.HI/c1-6-12-14(11,13-7-2)15-9-8-10(3,4)5;/h6-9H2,1-5H3;1H/q+1;/p-1
InChi Key
OVXQHPWHMXOFRD-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    Product Description

    Echothiophate is an organophosphate and acetylcholinesterase (AChE) inhibitor.1 It is more active at ocular acetylcholinesterases than those isolated from rabbit brain, liver, or blood. In vivo, topical ocular administration of echothiophate (0.125 and 0.25% w/v) reduces intraocular pressure and induces miosis in dogs with normotensive eyes and those with inherited glaucoma.2 It also induces formation of subcapsular cataracts in cynomolgus monkeys.3 Formulations containing echothiophate have been used for the treatment of glaucoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ellis, P.P. Ocular tissue cholinesterases kinetics of enzyme activity and inhibition. Trans. Am. Opthalmol. Soc. 69, 358-382 (1971).

    2. Gum, G.G., Gelatt, K.N., Gelatt, J.K., et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am. J. Vet. Res. 54(2), 287-293 (1993).

    3. Kaufman, P.L., Axelsson, U., and Bárány, E.H. Induction of subcapsular cataracts in cynomolgus monkeys by echothiophate. Arch. Opthalmol. 95(3), 499-504 (1977).