A mineralocorticoid agonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Fludrocortisone Acetate

Item No. 24032

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-(acetyloxy)-9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione
CAS Number
514-36-3
Synonyms
  • 9α-fluoro Hydrocortisone Acetate
  • NSC 15186
  • U 4845
Molecular Formula
C23H31FO6
Formula Weight
422.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
λmax
239 nm
SMILES
F[C@]12[C@@]([C@@](CC[C@]3(O)C(COC(C)=O)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O
InChi Code
InChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
InChi Key
SYWHXTATXSMDSB-GSLJADNHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 mg

    $36

    Add

    500 mg

    $63

    Add

    1 g

    $96

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist.1 Fludrocortisone acetate (0.1-5 µg/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 µg/animal.2 Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Agarwal, M.K., Coupry, F., and Philippe, M. Physiological activity and receptor binding of 9α fluorohydrocortisone. Biochem. Biophys. Res. Commun. 78(2), 747-753 (1977).

    2. Stafford, R.O., Barnes, L.E., Bowman, B.J., et al. Glucocorticoid and mineralocorticoids activities of Delta1-fluorohydrocortisone. Proc. Soc. Exp. Biol. Med. 89(3), 371-374 (1955).