A somatostatin receptor agonist
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Lanreotide (acetate)

Item No. 24084

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-cyclic (2→7)-disulfide, L-threoninamide, acetate
CAS Number
127984-74-1
Synonyms
  • BIM23014
Molecular Formula
C54H69N11O10S2 • XC2H4O2
Formula Weight
1096.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
O=C1[C@H](C(C)C)NC([C@@](CCCCN)([H])NC([C@@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CC=C(O)C=C4)NC([C@](NC([C@H](N)CC5=CC(C=CC=C6)=C6C=C5)=O)([H])CSSC[C@@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)N1)=O)=O)=O)=O.OC(C)=O
InChi Code
InChI=1S/C54H69N11O10S2.C2H4O2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55;1-2(3)4/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74);1H3,(H,3,4)/t30-,38-,40+,41+,42-,43+,44+,45+,46+;/m1./s1
InChi Key
DEXPIBGCLCPUHE-UISHROKMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    Cayman Chemical
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    Product Description

    Lanreotide is a peptide analog of somatostatin that binds to somatostatin receptors (SSTRs) with a higher affinity for the somatostatin subgroup 2 receptors SST2, SST3, and SST5 (IC50s = 0.5-1.8, 43-107, and 5.6-32 nM, respectively) than for the subgroup 1 receptors, SST1 and SST4 (IC50s = 500-2,330 and 66-2,100 nM, respectively).1 Lanreotide (100 nM) inhibits the release of growth hormone from patient-derived pituitary adenoma cells in vitro.2 It also inhibits tumor growth in human small cell lung cancer (SCLC) mouse xenograft models when administered at a dose of 250 µg, twice daily.3 Formulations containing lanreotide have been used in the treatment of acromegaly and neuroendocrine tumors.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patel, Y.C. Somatostatin and its receptor family. Front. Neuroendocrinol. 20(3), 157-198 (1999).

    2. Shimon, I., Yan, X., Taylor, J.E., et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J. Clin. Invest. 100(9), 2386-2392 (1997).

    3. Prevost, G., Bourgeois, Y., Mormont, C., et al. Characterization of somatostatin receptors and growth inhibition by the somatostatin analogue BIM23014 in small cell lung carcinoma xenograft: SCLC-6. Life Sci. 55(2), 155-162 (1994).