A steroid-based neuromuscular blocker reversing agent
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Sugammadex (sodium salt)

Item No. 24096

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin, octosodium salt
CAS Number
343306-79-6
Synonyms
  • ORG 25969
Molecular Formula
C72H104O48S8 • 8Na
Formula Weight
2178.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 2.5 mg/mlDMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
SMILES
[H][C@]12O[C@]3([H])[C@H](O)[C@@H](O)[C@@](O[C@@]4([H])O[C@H](CSCCC([O-])=O)[C@](O[C@@]5([H])O[C@H](CSCCC([O-])=O)[C@](O[C@@]6([H])O[C@H](CSCCC([O-])=O)[C@](O[C@@]7([H])O[C@H](CSCCC([O-])=O)[C@](O[C@@]8([H])O[C@H](CSCCC([O-])=O)[C@](O[C@@]9([H])O[C@H](CSCCC([O-])=O)[C@](O[C@](O[C@@H]2CSCCC([O-])=O)([H])[C@H](O)[C@H]1O)([H])[C@H](O)[C@H]9O)([H])[C@H](O)[C@H]8O)([H])[C@H](O)[C@H]7O)([H])[C@H](O)[C@H]6O)([H])[C@H](O)[C@H]5O)([H])[C@H](O)[C@H]4O)([H])[C@@H](CSCCC([O-])=O)O3.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C72H112O48S8.8Na/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90;;;;;;;;/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88);;;;;;;;/q;8*+1/p-7/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-;;;;;;;;/m1......../s1
InChi Key
KMGKABOMYQLLDJ-VKHHSAQNSA-G
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    Product Description

    Sugammadex is a synthetic derivative of γ-cyclodextrin and a steroid-based neuromuscular blocker reversing agent.1 It binds rocuronium (Item No. 23698) within its cyclodextrin ring and selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium (Item No. 23610) or atracurium (Item No. 17796) in anesthetized rhesus monkeys. Sugammadex also prevents formation of postoperative peritoneal adhesions in rats.2 In a rat model of ischemia-reperfusion injury, sugammadex (16 and 100 mg/kg) increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Boer, H.D., van Egmond, J., van de Pol, F., et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br. J. Anaesth. 96(4), 473-479 (2006).

    2. Şahin, H., Toman, H., Kiraz, H.A., et al. Effects of sugammadex on the prevention of postoperative peritoneal adhesions. Kaohsiung J. Med. Sci. 31(9), 463-467 (2015).

    3. Ozbilgin, S., Yilmaz, O., Ergur, B.U., et al. Effectiveness of sugammadex for cerebral ischemia/reperfusion injury. Kaohsiung, J. Med. Sci. 32(6), 292-301 (2016).