A biologically active form of Vitamin B12
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Hydroxocobalamin

Item No. 24099

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
co-hydroxy-cobinamide, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
CAS Number
13422-51-0
Synonyms
  • Hydroxycobalamin
  • Vitamin B12a
Molecular Formula
C62H89CoN13O15P
Formula Weight
1346.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly SolubleWater: Slightly Soluble
SMILES
[OH-][Co+3]123([N]4=CN(C(OC(CO)C5O[P]6([O-])=O)C5O)C7=C4C=C(C)C(C)=C7)[N]8=C9C(CCC(N)=O)C(CC(N)=O)(C)C8(C)C(C(CC(N)=O)C%10(CCC(NCC(C)O6)=O)C)[N-]1C%10=C(C)C(C(CCC(N)=O)C%11(C)C)=[N]2C%11=CC%12=[N]3C(C(C)(CC(N)=O)C%12CCC(N)=O)=C9C
InChi Code
InChI=1S/C62H90N13O14P.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;1H2/q;+3;/p-3
InChi Key
YOZNUFWCRFCGIH-UHFFFAOYSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $98

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    25 mg

    $231

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    Product Description

    Hydroxocobalamin is a biologically active form of vitamin B12 (Item No. 18425).1 It increases the number of red blood cells 2.5-fold over control in a mouse model of anemia when administered at a dose of 2 µg per day for 4 days.2 Hydroxocobalamin is also efficacious in animal models of cyanide poisoning.1 Formulations containing hydroxocobalamin have been used in the treatment of vitamin B12 deficiency and cyanide poisoning.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thompson, J.P., and Marrs, T.C. Hydroxocobalamin in cyanide poisoning. Clin. Toxicol. (Phila) 50(10), 875-885 (2012).

    2. Vijayaraghavan, P.K., and Dunn, M.S. Effect of vitamins B12, B12a and B12b on red blood cell counts in experimental anemia in mice. Arch. Biochem. Biophys. 31(2), 248-250 (1951).