A hepatitis C virus NS5A inhibitor
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Ombitasvir

Item No. 24116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2'-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-L-prolinamide
CAS Number
1258226-87-7
Synonyms
  • ABT-267
Molecular Formula
C50H67N7O8
Formula Weight
894.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
252 nm
SMILES
CC(C)(C)C(C=C1)=CC=C1N2[C@H](C3=CC=C(NC([C@@H]4CCCN4C([C@@H](NC(OC)=O)C(C)C)=O)=O)C=C3)CC[C@H]2C5=CC=C(NC([C@H]6N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC6)=O)C=C5
InChi Code
InChI=1S/C50H67N7O8/c1-30(2)42(53-48(62)64-8)46(60)55-28-10-12-40(55)44(58)51-35-20-14-32(15-21-35)38-26-27-39(57(38)37-24-18-34(19-25-37)50(5,6)7)33-16-22-36(23-17-33)52-45(59)41-13-11-29-56(41)47(61)43(31(3)4)54-49(63)65-9/h14-25,30-31,38-43H,10-13,26-29H2,1-9H3,(H,51,58)(H,52,59)(H,53,62)(H,54,63)/t38-,39-,40-,41-,42-,43-/m0/s1
InChi Key
PIDFDZJZLOTZTM-KHVQSSSXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).1,2 It reduces HCV replication in stable replicon cell lines with EC50 values ranging from 0.82 to 19.3 pM against genotypes 1a, 1b, 2a, 2b, 3a, 4a, and 5a and an EC50 value of 366 pM for genotype 6a.1,2 Against subgenomic replicons from clinical isolates of genotypes 1a-6a expressed in Huh-7 derived cells, ombitasvir inhibits HCV replication with EC50 values ranging from 0.1 pM for genotype 4a to 68 pM for genotype 6a.2 Formulations containing ombitasvir have been used in the treatment of HCV genotypes 1 and 4.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, X. Direct anti-HCV agents. Acta Pharmaceutica Sinica B 6(1), 26-31 (2015).

    2. Krishnan, P., Beyer, J., Mistry, N., et al. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A. Antimicrob. Agents Chemother. 59(2), 979-987 (2015).