A PAR1 agonist
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TRAP-6 Peptide (trifluoroacetate salt)

Item No. 24125

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparagine, trifluoroacetate salt
Synonyms
  • Ser-Phe-Leu-Leu-Arg-Asn
  • Thrombin Receptor Agonist Peptide-6
Molecular Formula
C34H56N10O9 • XCF3COOH
Formula Weight
748.9
Purity
≥95%
Formulation
A lyophilized powder
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)[C@@H](NC([C@H](CO)N)=O)CC1=CC=CC=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C34H56N10O9.C2HF3O2/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20;3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39);(H,6,7)/t21-,22-,23-,24-,25-,26-;/m0./s1
InChi Key
MYWDHZOZDWFXCS-POCCEKOUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $128

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    Product Description

    TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1).1 It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC50 = 0.8 µM). TRAP-6 (0.3 and 0.6 mg/kg) has a triphasic effect on mean arterial blood pressure (MAP) in anesthetized rats with a short decrease, an increase, and then a longer decrease in MAP following intravenous administration.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vassallo, R.R., Jr., Kieber-Emmons, T., Chichowski, K., et al. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. The Journal of Biological Chemisty 267(9), 6081-6085 (1992).

    2. Sicker, T., Wuchold, F., Kaiser, B., et al. Systemic vascular effects of thrombin and thrombin receptor activating peptide in rats. Thromb. Res. 101(6), 467-475 (2001).