A fluorogenic substrate for MMPs
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Mca-PLGL-Dap(Dnp)-AR-NH2 (trifluoroacetate salt)

Item No. 24149

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-L-argininamide, 2,2,2-trifluoroacetate
Synonyms
  • Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
  • 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
Molecular Formula
C49H68N14O15 • XCF3COOH
Formula Weight
1093.2
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)CNC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1)=O)=O)=O)[C@H]2N(C(CC3=CC(OC4=CC(OC)=CC=C43)=O)=O)CCC2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C49H68N14O15.C2HF3O2/c1-25(2)17-34(59-48(72)37-10-8-16-61(37)41(65)19-28-20-42(66)78-39-22-30(77-6)12-13-31(28)39)45(69)55-24-40(64)57-35(18-26(3)4)46(70)60-36(23-54-32-14-11-29(62(73)74)21-38(32)63(75)76)47(71)56-27(5)44(68)58-33(43(50)67)9-7-15-53-49(51)52;3-2(4,5)1(6)7/h11-14,20-22,25-27,33-37,54H,7-10,15-19,23-24H2,1-6H3,(H2,50,67)(H,55,69)(H,56,71)(H,57,64)(H,58,68)(H,59,72)(H,60,70)(H4,51,52,53);(H,6,7)/t27-,33-,34-,35-,36-,37-;/m0./s1
InChi Key
RCGDCRQKECJNLZ-XDJSNLLDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $127

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    1 mg

    $239

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    Product Description

    Mca-PLGL-Dap(Dnp)-AR-NH2 is a fluorogenic peptide substrate for matrix metalloproteinases (MMPs).1 Upon cleavage by an MMP, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca has excitation and emission maxima of 328 and 420 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edkins, T.J., Alhadeff, J.A., Kwok, V., et al. Development and validation of novel enzyme activity methods to assess inhibition of matrix metalloproteinases (MMPs) in human serum by antibodies against enzyme therapeutics. J. Pharm. Biomed. Anal. 70, 408-414 (2012).