A peptide hormone with vasoconstrictive and antidiuretic activities
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Argipressin (acetate)

Item No. 24154

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-L-arginine-vasopressin, acetate
CAS Number
129979-57-3
Synonyms
  • AVP
  • Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
  • [Arg8]-Vasopressin
Molecular Formula
C46H65N15O12S2 • XC2H4O2
Formula Weight
1084.2
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Peptide Sequence
CYFQNCPRG-NH2
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
N[C@@H](CSSC[C@@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)=O)NC([C@H](CC(N)=O)N2)=O)C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CCC(N)=O)C2=O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C46H65N15O12S2.C2H4O2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25;1-2(3)4/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53);1H3,(H,3,4)/t27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
InChi Key
ZHFGXNMADRRGQP-HPILINOVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    Product Description

    Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively.1,2 It also stimulates the intracellular release of calcium in A7r5 cells (EC50 = 5 nM).3 In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thibonnier, M., Bayer, A.L., Simonson, M.S., et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology 129(6), 2845-2856 (1991).

    2. Xu, Y.J., and Gopalakrishnan, V. Vasopressin increases cytosolic free [Ca2+] in the neonatal rat cardiomyocyte. Evidence for V1 subtype receptors. Circ. Res. 69(1), 239-245 (1991).

    3. Byron, K.L. Vasopressin stimulates Ca2+ spiking activity in A7r5 vascular smooth muscle cells via activation of phospholipase A2. Circ. Res. 78(5), 813-820 (1996).

    4. Gao, L., Jiang, N.-C., Luo, Q.-H., et al. Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats. Zhongguo Yao Li Xue Bao. 17(1), 49-52 (1996).

    5. Jiang, N.-C., Gao, L., Chen, C., et al. Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in rats. Zhongguo Yao Li Xue Bao. 14(2), 118-120 (1993).