An 11-residue amyloid-β protein fragment
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Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

Item No. 24155

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionine, trifluoroacetate salt
Synonyms
  • Aβ (25-35)
Molecular Formula
C45H81N13O14S • XCF3COOH
Formula Weight
1060.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CO)=O)CC(N)=O)=O)CCCCN)=O)=O)C)=O)[C@H](CC)C)N[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(O)=O)=O)CC(C)C)=O)=O)[C@H](CC)C.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C45H81N13O14S.C2HF3O2/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47;3-2(4,5)1(6)7/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72);(H,6,7)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-;/m0./s1
InChi Key
ALHHDLMFVTWOLX-BZDKSGIQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $70

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    1 mg

    $129

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    Product Description

    Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide.1 It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-β arrangement of β-strands similar to Aβ (1-40) (Item No. 21617) and Aβ (1-42) (Item No. 20574) fibrils.2,3 Aggregated Aβ (25-35) decreases the viability of rat adrenal PC12 cells.2 It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 μM.4 In vivo, intracerebral injection of Aβ (25-35) (20 nmol) in rats induces lesions of neuronal and tissue loss.5 Aggregated Aβ (25-35) administered intracerebroventricularly to rats induces learning and memory impairments in the Y-maze, novel object recognition, and contextual fear conditioning tests.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaminsky, Y.G., Marlatt, M.W., Smith, M.A., et al. Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: evidence for Abeta25-35. Exp. Neurol. 221(1), 26-37 (2010).

    2. Hughes, E., Burke, R.M., and Doig, A.J. Inhibition of toxicity in the β-amyloid peptide fragment β-(25–35) using N-methylated derivatives. The Journal of Biological Chemisty 275(33), 25109-25115 (2000).

    3. Wei, G., Jewett, A.I., and Shea, J.E. Structural diversity of dimers of the Alzheimer amyloid-β(25-35) peptide and polymorphism of the resulting fibrils. Phys. Chem. Chem. Phys. 12(14), 3622-3629 (2010).

    4. Wang, Y., Liu, L., Hu, W., et al. Mechanism of soluble beta-amyloid 25-35 neurotoxicity in primary cultured rat cortical neurons. Neurosci. Lett. 618, 72-76 (2016).

    5. Rush, D.K., Aschmies, S., and Merriman, M.C. Intracerebral β-amyloid(25-35) produces tissue damage: Is it neurotoxic. Neurobiol. Aging 13(5), 591-594 (1992).

    6. Tsunekawa, H., Noda, Y., Mouri, A., et al. Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25-35). Behav. Brain Res. 190(2), 224-232 (2008).