A fluoroquinolone antibiotic
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Fleroxacin

Item No. 24173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
CAS Number
79660-72-3
Synonyms
  • AM833
  • Ro 23-6240
Molecular Formula
C17H18F3N3O3
Formula Weight
369.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.1 mg/mlDMSO: 15 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
210, 291 nm
SMILES
CN1CCN(C2=C(F)C=C(C(C(C(O)=O)=CN3CCF)=O)C3=C2F)CC1
InChi Code
InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
InChi Key
XBJBPGROQZJDOJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Fleroxacin is a broad-spectrum fluoroquinolone antibiotic.1 It is active against a variety of Gram-positive and Gram-negative bacteria with MIC90 values ranging from 0.05 to 3.13 µg/ml for clinical isolates of Staphylococcus, P. aeruginosa, H. influenzae, N. gonorrhoeae, B. catarrhalis, C. jejuni, and various species of Enterobacteriaceae. Fleroxacin inhibits bacterial DNA replication with IC50 values of 82.6 and 31.6 µg/ml for S. aureus DNA gyrase and topoisomerase IV, respectively.2 Fleroxacin is active in vivo with ED50 values ranging from 0.8 to 16.6 mg/kg in mice with systemic bacterial infections.1 It also reduces E. coli in the kidney in a mouse model of urinary tract infection when administered at doses of 0.625 and 10 mg/kg twice daily. Formulations containing fleroxacin have been used in the treatment of uncomplicated cystitis, gonorrhea, bacterial enteritis, traveler's diarrhea, and urinary tract infections.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hirai, K., Aoyama, H., Hosaka, M., et al. In vitro and in vivo antibacterial activity of AM-833, a new quinolone derivative. Antimicrob. Agents Chemother. 29(6), 1059-1066 (1986).

    2. Takei, M., Fukuda, H., Kishii, R., et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob. Agents Chemother. 45(12), 3544-3547 (2001).

    3. Naber, K.G. Fleroxacin overview. Chemotherapy 42(Suppl 1), 1-9 (1996).