A fungal metabolite
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Citromycetin

Item No. 24175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,9-dihydroxy-2-methyl-4-oxo-4H,5H-pyrano[3,2-c][1]benzopyran-10-carboxylic acid
CAS Number
478-60-4
Synonyms
  • NSC 53584
Molecular Formula
C14H10O7
Formula Weight
290.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
OC1=C(O)C=C(OCC2=C3OC(C)=CC2=O)C3=C1C(O)=O
InChi Code
InChI=1S/C14H10O7/c1-5-2-7(15)6-4-20-9-3-8(16)12(17)11(14(18)19)10(9)13(6)21-5/h2-3,16-17H,4H2,1H3,(H,18,19)
InChi Key
PKEPGKZPVDAVKI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $374

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    5 mg

    $1,584

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    Product Description

    Citromycetin is a fungal metabolite originally isolated from P. frequentans with antibiotic activity against the Gram-positive bacteria S. aureus and the Gram-negative bacteria V. cholerae and S. flexneri (MICs = 64 µg/ml for both).1,2 Citromycetin is selectively cytotoxic to cancerous cells over non-cancerous cells (LC50s = 9.21 and 261.14 µg/ml for HeLa and Vero cells, respectively). Formulations containing citromycetin have been studied for use in the treatment of amyloidosis and α-synuclein fibril diseases.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grove, J.F., and Brian, P.W. Identity of frequentic acid and citromycetin. Nature 167(4259), 995 (1951).

    2. Jouda, J.-B., Tamokou, D.-d.-D., Mbazoa, C.D., et al. Anticancer and antibacterial secondary metabolites from the endophytic fungus Penicillium sp. CAM64 against multi-drug resistant Gram-negative bacteria. Afr. Health Sci. 16(3), 734-743 (2016).

    3. Castillo, G.M., Choi, P.Y., and Snow, A.D. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and α-synuclein fibril diseases. (2001).