A peptide NK2 receptor agonist
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Neurokinin A (trifluoroacetate salt)

Item No. 24221

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-L-lysyl-L-threonyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-valylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt
Synonyms
  • Neurokinin α
  • Neuromedin L
  • Substance K
Molecular Formula
C50H80N14O14S • XCF3COOH
Formula Weight
1133.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(N[C@@H](CCCCN)C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)C(C)C)=O)CC1=CC=CC=C1)=O)=O)CC(O)=O)=O)=O)[C@@H](N)CC2=CNC=N2.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C50H80N14O14S.C2HF3O2/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30;3-2(4,5)1(6)7/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69);(H,6,7)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+;/m1./s1
InChi Key
CPQMHLIZWAQHOV-LEUAYMAXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $128

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    5 mg

    $589

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    Product Description

    Neurokinin A is a peptide agonist of the neurokinin-2 (NK2) receptor.1,2,3 It potentiates electrically-induced contractions of isolated rat vas deferens and increases vasodilation in the rat hind paw.2 Neurokinin A (0.3-30 nmol/kg, i.v.) induces bronchoconstriction in guinea pigs in a dose-dependent manner (EC50 = 29 nM), an effect which can be reversed by the NK2 receptor antagonist MEN 10,207.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maggi, C.A., Giuliani, S., Ballati, L., et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J. Pharmacol. Exp. Ther. 257(3), 1172-1178 (1991).

    2. Holzer-Petsche, U., Schimek, E., Amann, R., et al. In vivo and in vitro actions of mammalian tachykinins. Naunyn Schmiedebergs Arch. Pharmacol. 330(2), 130-135 (1985).

    3. Laneuville, O., Couture, R., and Pace-Asciak, C.R. Neurokinin A-induced contraction of guinea-pig isolated trachea: Potentiation by hepoxilins. Br. J. Pharmacol. 107(3), 808-812 (1992).