A tropic hormone
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Gonadorelin (acetate)

Item No. 24240

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
luteinizing hormone-releasing factor (swine), acetate
CAS Number
34973-08-5
Molecular Formula
C55H75N17O13 • XC2H4O2
Formula Weight
1182.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 0.25 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
221, 276 nm
SMILES
O=C(N[C@@H](CO)C(N[C@@H](CC1=CC=C(O)C=C1)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(NCC(N)=O)=O)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC3=CNC=N3)NC([C@H]4NC(CC4)=O)=O)=O)CC5=CNC6=C5C=CC=C6.OC(C)=O
InChi Code
InChI=1S/C55H75N17O13.C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);1H3,(H,3,4)/
InChi Key
NGCGMRBZPXEPOZ-HBBGHHHDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 mg

    $36

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    10 mg

    $68

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    25 mg

    $153

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    Product Description

    Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor).1 It stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg.2 It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM.3 In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (Item No. 23555; ED50 = 610.3 ng/kg).4 Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nederpelt, I., Georgi, V., Schiele, F., et al. Characterization of 12 GnRH peptide agonists - a kinetic perspective. Br. J. Pharmacol. 173(1), 128-141 (2016).

    2. Yanaihara, N., Yanaihara, C., Sakagami, M., et al. Synthesis and biological evaluation of LH and FSH releasing hormone and its analogs. J. Med. Chem. 16(4), 373-377 (1973).

    3. Bellmann, A., Schneider, F., Kanitz, W., et al. Effect of GnRH and its antagonist (Antarelix) on LH release from cultured bovine anterior pituitary cells. Acta Vet. Hung. 50(1), 79-92 (2002).

    4. Banik, U.K., and Givner, M.L. Simple potency test for LH-RH preparations. J. Biol. Stand. 8(2), 151-156 (1980).