An inhibitor of autotaxin
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BI-2545

Item No. 24285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-bis(trifluoromethyl)benzyl (1R,5S,6s)-6-((1H-benzo[d][1,2,3]triazole-6-carboxamido)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
CAS Number
2162961-71-7
Molecular Formula
C23H19F6N5O3
Formula Weight
527.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
213 nm
SMILES
[H][C@]12[C@](CN(C(OCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O)C2)([H])[C@@H]1CNC(C4=CC(N=NN5)=C5C=C4)=O
InChi Code
InChI=1S/C23H19F6N5O3/c24-22(25,26)13-3-11(4-14(6-13)23(27,28)29)10-37-21(36)34-8-16-15(17(16)9-34)7-30-20(35)12-1-2-18-19(5-12)32-33-31-18/h1-6,15-17H,7-10H2,(H,30,35)(H,31,32,33)/t15-,16-,17+
InChi Key
ZDOBSAPHUUUOHX-OSYLJGHBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $204

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    25 mg

    $481

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    Product Description

    BI-2545 is an inhibitor of autotaxin (IC50s = 2.2 and 3.4 for the human and rat enzyme, respectively).1 It is selective for autotaxin over a panel of 48 enzymes, transporters, ion channels, and receptors at 10 µM. BI-2545 (10 mg/kg) reduces plasma lysophosphatidic acid (LPA) levels in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuttruff, C.A., Ferrara, M., Bretschneider, T., et al. Discovery of BI-2545: A novel autotaxin inhibitor that significantly reduces LPA levels in vivo. ACS Med. Chem. Lett. 8(12), 1252-1257 (2017).