A telomerase inhibitor
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MST-312

Item No. 24301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N'-1,3-phenylenebis[2,3-dihydroxy-benzamide
CAS Number
368449-04-1
Synonyms
  • Telomerase Inhibitor IX
Molecular Formula
C20H16N2O6
Formula Weight
380.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:40): 0.025 mg/mlEthanol: 0.2 mg/ml
λmax
213, 274 nm
SMILES
OC1=C(O)C(C(NC2=CC=CC(NC(C3=C(O)C(O)=CC=C3)=O)=C2)=O)=CC=C1
InChi Code
InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
InChi Key
MIQUEZGHEJGPJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $183

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    Cayman Chemical
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    Product Description

    MST-312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay).1 It is selective for telomerase over DNA polymerase when used at concentrations up to 3 μM. MST312 inhibits growth of U937 cells via telomere shortening (GI50 = 1.7 μM). It reduces cell number and expression of the proliferation marker MIB-1 as well as increases DNA damage in primary pediatric ependymoma tumor cells.2 MST-312 decreases survival of H460 and H1299 non-small cell lung cancer (NSCLC) cells in a dose-dependent manner with a greater effect on the aldehyde dehydrogenase positive (ALDH+) cancer stem cell population.3 In vivo, MST-312 (40 mg/kg) reduces tumor size by 70% in an H460 mouse xenograft model. MST-312 also inhibits replication of herpes simplex virus 2 (HSV-2) and a clinical isolate of HSV-1 and decreases accumulation of early and late viral proteins in HEp-2 cells infected with HSV-1.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seimiya, H., Oh-hara, T., Suzuki, T., et al. Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. Mol. Cancer Ther. 1(9), 657-665 (2002).

    2. Wong, V.C.H., Morrison, A., Tabori, U., et al. Telomerase inhibition as a novel therapy for pediatric ependymoma. Brain Pathol. 20(4), 780-786 (2010).

    3. Serrano, D., Bleau, A.-M., Fernandez-Garcia, I., et al. Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer. Mol. Cancer 10(96), (2011).

    4. Haberichter, J., Roberts, S., Abbasi, I., et al. The telomerase inhibitor MST-312 interferes with multiple steps in the herpes simplex virus life cycle. J. Virol. 89(19), 9804-9816 (2015).