A selective GABAA-ρ1 (ρ1 GABAC) receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TPMPA (hydrate)

Item No. 24302

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-phosphinic acid, hydrate
Molecular Formula
C6H12NO2P • XH2O
Formula Weight
161.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
CP(C1=CCNCC1)(O)=O.O
InChi Code
InChI=1S/C6H12NO2P.H2O/c1-10(8,9)6-2-4-7-5-3-6;/h2,7H,3-5H2,1H3,(H,8,9);1H2
InChi Key
GXVWAQPRAQORGS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $40

    Add

    5 mg

    $132

    Add

    10 mg

    $207

    Add

    25 mg

    $469

    Add
    Product Description

    TPMPA is a GABAA-ρ1 (ρ1 GABAC) receptor antagonist that is 8-fold selective for GABAA-ρ1 over GABAA-ρ2 (ρ2 GABAC) receptors expressed in X. laevis oocytes (Kbs = 2 and 16 μM, respectively).1 In rat hippocampal slices, TPMPA blocks the inhibitory effect of the GABAB agonist 3-APMPA on excitatory postsynaptic currents (EPSCs) with an EC50 value of 490 μM.2 TPMPA (100 μM) increases light sensitivity and the maximal response of rat retinal ganglion cells without altering their dynamic range.3 In sleeping rats, TPMPA (50 μg, i.c.v.) increases waking from 45 to 62% compared to a vehicle control and decreases slow-wave and paradoxical sleep (REM) by 11 and 5.4%, respectively.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chebib, M., Mewett, K.N., and Johnston, G.A. GABAC receptor antagonists differentiate between human ρ1 and ρ2 receptors expressed in Xenopus oocytes. Eur. J. Pharmacol. 357(2-3), 227-234 (1998).

    2. Ragozzino, D., Woodward, R.M., Murata, Y., et al. Design and in vitro pharmacology of a selective γ-aminobutyric acidC receptor antagonist. Mol. Pharmacol. 50(4), 1024-1030 (1996).

    3. Jensen, R.J. Blocking GABAC receptors increases light responsiveness of retinal ganglion cells in a rat model of retinitis pigmentosa. Exp. Eye Res. 105, 21-26 (2012).

    4. Arnaud, C., Gauthier, P., and Gottesmann, C. Study of a GABAC receptor antagonist on sleep-waking behavior in rats. Psychopharmacology (Berl) 154(4), 415-419 (2001).