A caspase-9 inhibitor
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Caspase-9 Inhibitor III (trifluoroacetate salt)

Item No. 24306

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-leucyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-histidinamide, trifluoroacetate salt
Synonyms
  • Ac-LEHD-CMK
Molecular Formula
C24H35ClN6O9 • XCF3COOH
Formula Weight
587.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCC(O)=O)=O)N[C@H](C(CCl)=O)CC(O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C24H35ClN6O9.C2HF3O2/c1-12(2)6-17(28-13(3)32)23(39)29-15(4-5-20(34)35)22(38)31-18(7-14-10-26-11-27-14)24(40)30-16(8-21(36)37)19(33)9-25;3-2(4,5)1(6)7/h10-12,15-18H,4-9H2,1-3H3,(H,26,27)(H,28,32)(H,29,39)(H,30,40)(H,31,38)(H,34,35)(H,36,37);(H,6,7)/t15-,16-,17-,18-;/m0./s1
InChi Key
MLWGJZLAJSGXRI-YPFLJBJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $169

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    5 mg

    $319

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    10 mg

    $602

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    Product Description

    Caspase-9 inhibitor III is an inhibitor of caspase-9 with cardioprotective effects.1 It reduces infarct size, lactate dehydrogenase (LDH) and creatine kinase (CK) release, and DNA smearing induced by ischemia and reperfusion in isolated rat hearts. Caspase-9 inhibitor III also inhibits TnI proteolysis induced by matrix metalloproteinase-2 (MMP-2) when used at a concentration of 30 μM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sodhi, R.K., Singh, M., Singh, N., et al. Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. Arch. Pharm. Res. 32(7), 1037-1043 (2009).

    2. Castro, M.M., Fuah, J., Ali, M., et al. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. Biochem. Pharmacol. 86(4), 469-475 (2013).