A caspase-9 inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Caspase-9 Inhibitor III (trifluoroacetate salt)

Item No. 24306

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-leucyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-histidinamide, trifluoroacetate salt
Synonyms
  • Ac-LEHD-CMK
Molecular Formula
C24H35ClN6O9 • XCF3COOH
Formula Weight
587.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCC(O)=O)=O)N[C@H](C(CCl)=O)CC(O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C24H35ClN6O9.C2HF3O2/c1-12(2)6-17(28-13(3)32)23(39)29-15(4-5-20(34)35)22(38)31-18(7-14-10-26-11-27-14)24(40)30-16(8-21(36)37)19(33)9-25;3-2(4,5)1(6)7/h10-12,15-18H,4-9H2,1-3H3,(H,26,27)(H,28,32)(H,29,39)(H,30,40)(H,31,38)(H,34,35)(H,36,37);(H,6,7)/t15-,16-,17-,18-;/m0./s1
InChi Key
MLWGJZLAJSGXRI-YPFLJBJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $169

    Add

    5 mg

    $319

    Add

    10 mg

    $602

    Add
    Product Description

    Caspase-9 inhibitor III is an inhibitor of caspase-9 with cardioprotective effects.1 It reduces infarct size, lactate dehydrogenase (LDH) and creatine kinase (CK) release, and DNA smearing induced by ischemia and reperfusion in isolated rat hearts. Caspase-9 inhibitor III also inhibits TnI proteolysis induced by matrix metalloproteinase-2 (MMP-2) when used at a concentration of 30 μM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sodhi, R.K., Singh, M., Singh, N., et al. Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. Arch. Pharm. Res. 32(7), 1037-1043 (2009).

    2. Castro, M.M., Fuah, J., Ali, M., et al. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. Biochem. Pharmacol. 86(4), 469-475 (2013).