An antagonist of GluR5 subunit-containing kainate receptors
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UBP 302

Item No. 24309

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αS-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
CAS Number
745055-91-8
Molecular Formula
C15H15N3O6
Formula Weight
333.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mM
SMILES
O=C(O)C1=CC=CC=C1CN2C(N(C[C@H](N)C(O)=O)C=CC2=O)=O
InChi Code
InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)/t11-/m0/s1
InChi Key
UUIYULWYHDSXHL-NSHDSACASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $213

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    Product Description

    UBP 302 is an antagonist of glutamate receptor 5 (GluR5) subunit-containing kainate receptors that inhibits kainate-induced responses in isolated rat dorsal roots (Kd = 402 nM).1 In vitro, UBP 302 inhibits gamma frequency oscillations in the rat basolateral amygdala at a concentration of 25 µM, and blocks kainate receptor signaling in layer III neurons within the mouse medial entorhinal cortex at 20 µM, abrogating the intense synaptic activity characteristic of the Up state of cortical slow oscillation.2,3 In vivo, UBP 302 (250 mg/kg) significantly reduces seizure severity in a rat model of soman-induced status epilepticus.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. More, J.C., Nistico, R., Dolman, N.P., et al. Characterisation of UBP296: A novel, potent and selective kainate receptor antagonist. Neuropharmacology 47(1), 46-64 (2004).

    2. Randall, F.E., Whittington, M.A., and Cunningham, M.O. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur. J. Neurosci. 33(5), 914-922 (2011).

    3. Digby, R.J., Bravo, D.S., Paulsen, O., et al. Distinct mechanisms of Up state maintenance in the medial entorhinal cortex and neocortex. Neuropharmacology 113(Pt A), 543-555 (2017).

    4. Miller, S.L., Aroniadou-Anderjaska, V., Figueiredo, T.H., et al. A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists. Toxicol. Appl. Pharmacol. 284(2), 204-216 (2015).