A sphingolipid
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Galactosylceramide (bovine spinal cord)

Item No. 24322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-O-β-D-galactopyranosyl-ceramide
CAS Number
85305-88-0
Synonyms
  • Cerebroside
  • Galactosylcerebroside
  • GL1b
Molecular Formula
C48H93NO9 (for 2-hydroxy Tetracosanoyl)
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform:Methanol (2:1): Soluble
SMILES
O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](OC[C@H](NC([R])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@@H]1O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $169

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    Product Description

    Galactosylceramides are glycosphingolipids that contain galactose attached to a ceramide containing an N-acyl hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatide (Item No. 24323), found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system.1,2 Galactosylceramides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells.1,2,3 They accumulate in a globoid cell in the brain of patients with Krabbe disease, a disorder characterized by a deficiency in galactosylceramides activity.2 This product contains galactosylceramide molecular species with primarily C24:1, 2-hydroxy C18:0, and 2-hydroxy C24:0 fatty acyl chains. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1050]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boggs, J.M., Gao, W., Zhao, J., et al. Participation of galactosylceramide and sulfatide in glycosynapses between oligodendrocyte or myelin membranes. FEBS Lett. 584(9), 1771-1778 (2010).

    2. Wenger, D.A., Rafi, M.A., and Luzi, P. Krabbe disease: One hundred years from the bedside to the bench to the bedside. J. Neurosci. Res. 94(11), 982-989 (2016).

    3. Birkholz, A.M., Howell, A.R., and Kronenberg, M. The α and Ω of galactosylceramides in T cell immune function. The Journal of Biological Chemisty 290(25), 15365-15370 (2015).