A bioactive sphingolipid
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C12 Galactosylceramide (d18:1/12:0)

Item No. 24347

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R,3E)-1-[(β-D-galactopyranosyloxy)methyl]-2-hydroxy-3-heptadecen-1-yl]-dodecanamide
CAS Number
41613-14-3
Synonyms
  • N-Dodecanoyl-β-D-Galactosylceramide
  • Galactosylceramide (d18:1/12:0)
  • GalCer(d18:1/12:0)
Molecular Formula
C36H69NO8
Formula Weight
643.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: SolubleMethanol: Soluble
SMILES
O[C@H]1[C@@H](O)[C@@H](CO)O[C@@H](OC[C@H](NC(CCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@@H]1O
InChi Code
InChI=1S/C36H69NO8/c1-3-5-7-9-11-13-14-15-16-18-19-21-23-25-30(39)29(28-44-36-35(43)34(42)33(41)31(27-38)45-36)37-32(40)26-24-22-20-17-12-10-8-6-4-2/h23,25,29-31,33-36,38-39,41-43H,3-22,24,26-28H2,1-2H3,(H,37,40)/b25-23+/t29-,30+,31+,33-,34-,35+,36+/m0/s1
InChi Key
IYCYEZLMOLRFAN-XSXRAWBPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $70

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    5 mg

    $288

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    10 mg

    $502

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    50 mg

    $1,601

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    Product Description

    C12 Galactosylceramide is a bioactive sphingolipid.1,2,3 It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM.1 C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy.2 It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus.3 As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1937]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, J., Li, Q., Chang, Y.T., et al. Inhibitory activity of a ceramide library in interleukin-4 production from activated T cells. Bioorg. Med. Chem. 13(7), 2589-2595 (2005).

    2. Simova, J., Indrova, M., Bieblova, J., et al. Therapy for minimal residual tumor disease: β-Galactosylceramide inhibits the growth of recurrent HPV16-associated neoplasms after surgery and chemotherapy. Int. J. Cancer 126(12), 2997-3004 (2010).

    3. Morshed, S.R., Takahashi, T., Savage, P.B., et al. β-galactosylceramide alters invariant natural killer T cell function and is effective treatment for lupus. J. Clin. Immunol. 132(3), 321-333 (2009).