A peptide with diverse biological activities
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C-Type Natriuretic Peptide-22 (human, porcine, rat) (trifluoroacetate salt)

Item No. 24401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteine cyclic (6→22)-disulfide, trifluoroacetate salt
Synonyms
  • CNP-22
Molecular Formula
C93H157N27O28S3 • XCF3COOH
Formula Weight
2197.6
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]NCC(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(NCC1=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)CSSC[C@H](N1)C(O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C93H157N27O28S3.C2HF3O2/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98;3-2(4,5)1(6)7/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99);(H,6,7)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-;/m0./s1
InChi Key
PKYLOAOOPXCZHF-KGOAJLDVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.1,2,3 Its 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53.2 CNP-22 is a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively).1 It stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM).4,5 In vivo, CNP-22 (25 μg/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koller, K.J., and Goeddel, D.V. Molecular biology of the natriuretic peptides and their receptors. Circulation 86(4), 1081-1088 (1992).

    2. Barr, C.S., Rhodes, P., and Struthers, A.D. C-type natriuretic peptide. Peptides 17(7), 1243-1251 (1996).

    3. Pejchalova, K., Krejci, P., and Wilcox, W.R. C-natriuretic peptide: An important regulator of cartilage. Mol. Genet. Metab. 92(3), 210-215 (2007).

    4. Drewett, J.G., Fendly, B.M., Garbers, D.L., et al. Natriuretic peptide receptor-B (guanylyl cyclase-B) mediates C-type natriuretic peptide relaxation of precontracted rat aorta. The Journal of Biological Chemisty 270(9), 4668-4674 (1995).

    5. Mori, Y., Takayasu, M., Suzuki, Y., et al. Vasodilator effects of C-type natriuretic peptide on cerebral arterioles in rats. Eur. J. Pharmacol. 320(2-3), 183-186 (1997).

    6. Chen, G., Song, X., Yin, Y., et al. C-type natriuretic peptide prevents kidney injury and attenuates oxidative and inflammatory responses in hemorrhagic shock. Amino Acids 49(2), 347-354 (2017).