A calcium-like peptide
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CALP1 (trifluoroacetate salt)

Item No. 24402

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-alanyl-L-isoleucyl-L-threonyl-L-valyl-L-leucyl-L-valyl-L-lysine, trifluoroacetate salt
Synonyms
  • Calcium-like Peptide 1
Molecular Formula
C40H75N9O10 • XCF3COOH
Formula Weight
842.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
O=C([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)C(C)C)=O)CC(C)C)=O)C(C)C)=O)[C@@H](C)O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C40H75N9O10.C2HF3O2/c1-13-23(10)31(48-33(51)24(11)43-35(53)28(42)20(4)5)38(56)49-32(25(12)50)39(57)47-30(22(8)9)37(55)45-27(18-19(2)3)34(52)46-29(21(6)7)36(54)44-26(40(58)59)16-14-15-17-41;3-2(4,5)1(6)7/h19-32,50H,13-18,41-42H2,1-12H3,(H,43,53)(H,44,54)(H,45,55)(H,46,52)(H,47,57)(H,48,51)(H,49,56)(H,58,59);(H,6,7)/t23-,24-,25+,26-,27-,28-,29-,30-,31-,32-;/m0./s1
InChi Key
NEQKOMDEJDLJON-KIFCWDIHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $202

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    5 mg

    $897

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    Product Description

    CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.1 It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 µM) and apoptosis (IC50 = 44.78 µM).2 CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma.3 It also decreases radical production induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Villain, M., Jackson, P.L., Manion, M.K., et al. De novo design of peptides targeted to the EF hands of calmodulin. The Journal of Biological Chemisty 275(4), 2676-2685 (2000).

    2. Manion, M.K., Su, Z., Villain, M., et al. A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14(10), 1297-1306 (2000).

    3. Ten Broeke, R., Brandhorst, M.C., Leusink-Muis, T., et al. Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur. J. Pharmacol. 476(1-2), 151-157 (2003).