A calcium-like peptide
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CALP3 (trifluoroacetate salt)

Item No. 24403

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-lysyl-L-phenylalanylglycyl-L-valylglycyl-L-phenylalanyl-L-lysine, trifluoroacetate salt
Synonyms
  • Calcium-like peptide 3
Molecular Formula
C44H68N10O9 • XCF3COOH
Formula Weight
881.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 0.5 mg/ml
SMILES
O=C([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C(C)C)N)=O)CCCCN)=O)NCC(N[C@H](C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)C(C)C)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C44H68N10O9.C2HF3O2/c1-27(2)37(47)42(60)51-31(19-11-13-21-45)40(58)53-33(23-29-15-7-5-8-16-29)39(57)48-26-36(56)54-38(28(3)4)43(61)49-25-35(55)50-34(24-30-17-9-6-10-18-30)41(59)52-32(44(62)63)20-12-14-22-46;3-2(4,5)1(6)7/h5-10,15-18,27-28,31-34,37-38H,11-14,19-26,45-47H2,1-4H3,(H,48,57)(H,49,61)(H,50,55)(H,51,60)(H,52,59)(H,53,58)(H,54,56)(H,62,63);(H,6,7)/t31-,32-,33-,34-,37-,38-;/m0./s1
InChi Key
STLPIHXSDMTWNG-ORODDYLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $202

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    5 mg

    $897

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    Product Description

    CALP3 is a calcium-like peptide that contains the first eight residues of CALP2, which is a 12-residue peptide that interacts with EF hand motif 4 in human calmodulin to activate it in the absence of calcium.1 It acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons (IC50 = 37.25 µM) thereby inhibiting excitatory cytotoxicity (IC50 = 50.97 µM) and apoptosis (IC50 = 33.41 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Villain, M., Jackson, P.L., Manion, M.K., et al. De novo design of peptides targeted to the EF hands of calmodulin. The Journal of Biological Chemisty 275(4), 2676-2685 (2000).

    2. Manion, M.K., Su, Z., Villain, M., et al. A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14(10), 1297-1306 (2000).