A peptide vasoconstrictor
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Endothelin-2 (human) (trifluoroacetate salt)

Item No. 24412

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • ET-2 (human)
Molecular Formula
C115H160N26O32S4 • XCF3COOH
Formula Weight
2546.9
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@]([H])(NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@H](CC3=CNC=N3)NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(C=C5)O)NC([C@H](C(C)C)NC([C@]6(NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC7=O)=O)=O)=O)[H])=O)=O)=O)=O)CSSC[C@H](N)C(N[C@@H](CO)C(N[C@](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC8=CNC9=C8C=CC=C9)C(N[C@H]7CC(C)C)=O)=O)=O)=O)(CSSC6)[H])=O)=O)=O)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C115H160N26O32S4.C2HF3O2/c1-11-59(9)93(113(170)132-82(115(172)173)41-64-46-120-71-27-19-17-25-68(64)71)141-114(171)94(60(10)12-2)140-105(162)81(44-91(150)151)130-99(156)75(37-57(5)6)125-103(160)79(42-65-47-118-55-121-65)128-109(166)86-52-175-174-51-69(117)95(152)133-83(48-142)108(165)138-87-53-176-177-54-88(111(168)139-92(58(7)8)112(169)131-77(39-62-29-31-66(145)32-30-62)100(157)126-76(101(158)137-86)38-61-22-14-13-15-23-61)136-97(154)73(33-34-89(146)147)123-96(153)72(28-20-21-35-116)122-104(161)80(43-90(148)149)129-98(155)74(36-56(3)4)124-102(159)78(40-63-45-119-70-26-18-16-24-67(63)70)127-106(163)84(49-143)134-107(164)85(50-144)135-110(87)167;3-2(4,5)1(6)7/h13-19,22-27,29-32,45-47,55-60,69,72-88,92-94,119-120,142-145H,11-12,20-21,28,33-44,48-54,116-117H2,1-10H3,(H,118,121)(H,122,161)(H,123,153)(H,124,159)(H,125,160)(H,126,157)(H,127,163)(H,128,166)(H,129,155)(H,130,156)(H,131,169)(H,132,170)(H,133,152)(H,134,164)(H,135,167)(H,136,154)(H,137,158)(H,138,165)(H,139,168)(H,140,162)(H,141,171)(H,146,147)(H,148,149)(H,150,151)(H,172,173);(H,6,7)/t59-,60-,69-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,92-,93-,94-;/m0./s1
InChi Key
PNYUQHKZRVJPIS-JOTLSKGISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $362

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    1 mg

    $576

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    Product Description

    Endothelin-2 is a peptide vasoconstrictor and ligand for the endothelin (ET) receptors ETA and ETB (Kbs= 32.8 and 1.33 nM, respectively).1 It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s =8.75 and 8.55, respectively). Ex vivo, endothelin-2 induces vformal asoconstriction in isolated rat mesenteric arterial beds (ED50 = 90.8 pmol).2 Endothelin-2 also induces contraction of isolated rat uteri, an effect which is reversed by the ETA antagonist BQ-123 but not the ETB antagonist BQ-788 (Item No. 17403).3 Infusion of endothelin-2 restores vasoconstriction of vessels at the follicular apex of the ovarian follicle and ovulation in Amhr2cre/+Smo2 mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maguire, J.J., Kuc, R.E., Pell, V.R., et al. Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways. Life Sci. 91(13-14), 544-549 (2012).

    2. Douglas, S.A., and Hiley, C.R. Endothelium-dependent vascular activities of endothelin-like peptides in the isolated superior mesenteric arterial bed of the rat. Br. J. Pharmacol. 101(1), 81-88 (1990).

    3. Kousides, M., Story, M.E., and Pennefather, J.N. Endopeptidase 24.11 inhibition does not modify uterotonic effects of endothelins in rat uterus. Peptides 19(9), 1585-1593 (1998).

    4. Migone, F.F., Cowan, R.G., Williams, R.M., et al. In vivo imaging reveals an essential role of vasoconstriction in rupture of the ovarian follicle at ovulation. Proc. Natl. Acad. Sci. USA 113(8), 2294-2299 (2016).