A peptide vasoconstrictor
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Endothelin-3 (human, rat) (trifluoroacetate salt)

Item No. 24413

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan cyclic (1→15),(3→11)-bis(disulfide), 2,2,2-trifluoroacetate
Synonyms
  • ET-3
Molecular Formula
C121H168N26O33S4 • XCF3COOH
Formula Weight
2643.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@]([H])(NC([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@H](CC3=CNC=N3)NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CC5=CC=C(C=C5)O)NC([C@H](C(C)C)NC([C@]6(NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC7=O)=O)=O)=O)[H])=O)=O)=O)=O)CSSC[C@H](N)C(N[C@]([C@H](O)C)([H])C(N[C@](C(N[C@@H](CC8=CC=CC=C8)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC9=CC=C(O)C=C9)C(N[C@H]7CCCCN)=O)=O)=O)=O)(CSSC6)[H])=O)=O)=O)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C121H168N26O33S4.C2HF3O2/c1-11-62(7)97(117(175)139-89(121(179)180)49-70-53-126-77-25-17-16-24-75(70)77)145-118(176)98(63(8)12-2)144-112(170)88(52-95(157)158)136-105(163)81(44-60(3)4)131-109(167)86(50-71-54-125-59-127-71)134-113(171)90-56-182-181-55-76(124)101(159)146-99(64(9)148)120(178)142-91-57-183-184-58-92(115(173)143-96(61(5)6)116(174)137-84(48-69-32-38-74(152)39-33-69)107(165)132-82(108(166)141-90)46-67-28-34-72(150)35-29-67)140-104(162)80(40-41-93(153)154)130-102(160)78(26-18-20-42-122)129-110(168)87(51-94(155)156)135-103(161)79(27-19-21-43-123)128-106(164)83(47-68-30-36-73(151)37-31-68)138-119(177)100(65(10)149)147-111(169)85(133-114(91)172)45-66-22-14-13-15-23-66;3-2(4,5)1(6)7/h13-17,22-25,28-39,53-54,59-65,76,78-92,96-100,126,148-152H,11-12,18-21,26-27,40-52,55-58,122-124H2,1-10H3,(H,125,127)(H,128,164)(H,129,168)(H,130,160)(H,131,167)(H,132,165)(H,133,172)(H,134,171)(H,135,161)(H,136,163)(H,137,174)(H,138,177)(H,139,175)(H,140,162)(H,141,166)(H,142,178)(H,143,173)(H,144,170)(H,145,176)(H,146,159)(H,147,169)(H,153,154)(H,155,156)(H,157,158)(H,179,180);(H,6,7)/t62-,63-,64+,65+,76-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,96-,97-,98-,99-,100-;/m0./s1
InChi Key
KCCPSZQHPBNUIT-XWDNQLQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    Product Description

    Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively).1 It induces β-arrestin recruitment in CHO-K1 cells expressing human ETA and ETB (pD2s = 7.31 and 9.44, respectively). Endothelin-3 increases blood pressure in spontaneously hypertensive and normotensive rats when administered at doses of 310 and 955 pmol/kg, respectively.2 It also stimulates migration and adhesion of enteric neural crest cells (ENCCs) to the embryonic gut in mice via interaction with ETB.3 Mutations in the endothelin-3 gene, Edn3, induce distal aganglionosis caused by failed colonization of ENCCs in the hindgut and lack of ENCC migration to the ileo-caecal junction in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maguire, J.J., Kuc, R.E., Pell, V.R., et al. Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways. Life Sci. 91(13-14), 544-549 (2012).

    2. Watanabe, T.X., Kumagaye, S., Nishio, H., et al. Effects of endothelin-1 and endothelin-3 on blood pressure in conscious hypertensive rats. J. Cardiovasc. Pharmacol. 13(Suppl 5), S207-S208 (1989).

    3. Gazquez, E., Watanabe, Y., Broders-Bondon, F., et al. Endothelin-3 stimulates cell adhesion and cooperates with β1-integrins during enteric nervous system ontogenesis. Sci. Rep. 6(37877), 1-14 (2016).