A neuropeptide
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GRP (human) (trifluoroacetate salt)

Item No. 24415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-prolyl-L-leucyl-L-prolyl-L-alanylglycylglycylglycyl-L-threonyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-methionyl-L-tyrosyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-histidyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-L-methioninamide, 2,2,2-trifluoroacetate
Synonyms
  • Gastrin-Releasing Peptide (1-27) (human)
Molecular Formula
C130H204N38O31S2 • XCF3COOH
Formula Weight
2859.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CNC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@]([C@@H](C)O)([H])NC(CNC(CNC(CNC([C@@H](NC([C@@H]2CCCN2C([C@H](CC(C)C)NC([C@@H]3CCCN3C([C@H](C(C)C)N[H])=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)CC5=CN=CN5)=O)CC6=CNC7=C6C=CC=C7)=O)C)=O)=O)=O)CC8=CN=CN8)=O)=O)CCSC)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C130H204N38O31S2.C2HF3O2/c1-65(2)47-86(115(185)152-82(108(134)178)38-45-200-17)156-116(186)89(52-77-56-137-63-146-77)150-101(176)62-145-123(193)104(69(9)10)163-110(180)72(14)148-114(184)88(51-76-55-140-81-28-20-19-27-80(76)81)157-117(187)90(53-78-57-138-64-147-78)158-118(188)91(54-97(132)172)151-100(175)61-144-111(181)83(30-23-41-139-130(135)136)154-121(191)95-32-25-43-167(95)128(198)93(50-75-34-36-79(171)37-35-75)160-113(183)85(39-46-201-18)153-112(182)84(29-21-22-40-131)155-125(195)107(74(16)170)165-119(189)87(48-66(3)4)159-124(194)105(70(11)12)164-126(196)106(73(15)169)162-102(177)60-142-98(173)58-141-99(174)59-143-109(179)71(13)149-120(190)94-31-24-42-166(94)127(197)92(49-67(5)6)161-122(192)96-33-26-44-168(96)129(199)103(133)68(7)8;3-2(4,5)1(6)7/h19-20,27-28,34-37,55-57,63-74,82-96,103-107,140,169-171H,21-26,29-33,38-54,58-62,131,133H2,1-18H3,(H2,132,172)(H2,134,178)(H,137,146)(H,138,147)(H,141,174)(H,142,173)(H,143,179)(H,144,181)(H,145,193)(H,148,184)(H,149,190)(H,150,176)(H,151,175)(H,152,185)(H,153,182)(H,154,191)(H,155,195)(H,156,186)(H,157,187)(H,158,188)(H,159,194)(H,160,183)(H,161,192)(H,162,177)(H,163,180)(H,164,196)(H,165,189)(H4,135,136,139);(H,6,7)/t71-,72-,73+,74+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,103-,104-,105-,106-,107-;/m0./s1
InChi Key
HKAXCVHAKQHQJF-CZOHINJFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $356

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    Product Description

    Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release.1,2 It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM).3 GRP increases proliferation of human liver carcinoma HepG2 and MHCC97H cells but does not affect the proliferation of normal HL-7702 liver cells at a concentration of 1 nM.4 In vivo, GRP (0.35 nmol/kg/h) increases both pancreatic exocrine secretion and pancreatic polypeptide (PP) release in rats.5 It dose-dependently stimulates gastrin, pancreatic amylase, lipase, bilirubin, and acid output and induces gallbladder contraction in humans when administered at doses ranging from 1 to 27 pmol/kg per hour.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Spindel, E.R., Chin, W.W., Price, J., et al. Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc. Natl. Acad. Sci. USA 81(18), 5699-5703 (1984).

    2. Hildebrand, P., Drewe, J., Luo, H., et al. Role of cholecystokinin in mediating GRP-stimulated gastric, biliary and pancreatic functions in man. Regul. Pept. 41(2), 119-129 (1992).

    3. Dietrich, J.B., Hildebrand, P., Jeker, L.B., et al. Effects of BIM26226, a potent and specific bombesin receptor antagonist, on amylase release and binding of bombesin-like peptides to AR4-2J cells. Regul. Pept. 53(3), 165-173 (1994).

    4. Li, X., Lv, Y., Yuan, A., et al. Gastrin-releasing peptide promotes the growth of HepG2 cells via EGFR-independent ERK1/2 activation. Oncol. Rep. 24(2), 441-448 (2010).

    5. Miyasaka, K., Miyazaki, K., Funakoshi, A., et al. Effects of synthetic human gastrin-releasing peptide on pancreatic exocrine secretion and release of pancreatic polypeptide in conscious rats. Int. J. Pancreatol. 4(3), 251-260 (1989).