A neuropeptide
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GRP (porcine) (trifluoroacetate salt)

Item No. 24455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-prolyl-L-valyl-L-seryl-L-valylglycylglycylglycyl-L-threonyl-L-valyl-L-leucyl-L-alanyl-L-lysyl-L-methionyl-L-tyrosyl-L-prolyl-L-arginylglycyl-L-asparaginyl-L-histidyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-L-methioninamide, 2,2,2-trifluoroacetate
Synonyms
  • Porcine Gastrin-releasing Peptide 27
Molecular Formula
C126H198N38O31S2 • XCF3COOH
Formula Weight
2805.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC(CNC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@]([C@@H](C)O)([H])NC(CNC(CNC(CNC([C@H](C(C)C)NC([C@H](CO)NC([C@H](C(C)C)NC([C@@H]2CCCN2C([C@@H](N[H])C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)CCSC)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)CC5=CNC6=C5C=CC=C6)=O)C)=O)=O)=O)CC7=CN=CN7)=O)=O)CCSC)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C126H198N38O31S2.C2HF3O2/c1-62(2)44-83(155-121(191)102(67(11)12)162-123(193)103(71(16)166)158-98(173)56-138-94(169)54-137-95(170)55-140-120(190)100(65(7)8)160-116(186)90(59-165)157-122(192)101(66(9)10)161-118(188)92-31-24-40-163(92)124(194)68(13)128)110(180)144-69(14)105(175)149-81(28-21-22-38-127)108(178)150-82(37-43-197-18)109(179)156-89(46-72-32-34-76(167)35-33-72)125(195)164-41-25-30-91(164)117(187)151-80(29-23-39-135-126(131)132)107(177)139-57-96(171)147-88(50-93(129)168)115(185)154-87(49-75-53-134-61-143-75)114(184)153-85(47-73-51-136-78-27-20-19-26-77(73)78)111(181)145-70(15)106(176)159-99(64(5)6)119(189)141-58-97(172)146-86(48-74-52-133-60-142-74)113(183)152-84(45-63(3)4)112(182)148-79(104(130)174)36-42-196-17;3-2(4,5)1(6)7/h19-20,26-27,32-35,51-53,60-71,79-92,99-103,136,165-167H,21-25,28-31,36-50,54-59,127-128H2,1-18H3,(H2,129,168)(H2,130,174)(H,133,142)(H,134,143)(H,137,170)(H,138,169)(H,139,177)(H,140,190)(H,141,189)(H,144,180)(H,145,181)(H,146,172)(H,147,171)(H,148,182)(H,149,175)(H,150,178)(H,151,187)(H,152,183)(H,153,184)(H,154,185)(H,155,191)(H,156,179)(H,157,192)(H,158,173)(H,159,176)(H,160,186)(H,161,188)(H,162,193)(H4,131,132,135);(H,6,7)/t68-,69-,70-,71+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,99-,100-,101-,102-,103-;/m0./s1
InChi Key
WZHABQXROJXCMP-NBVJMIFUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release.1 It binds to GRP receptors on St42 human gastric cancer cells with an IC50 value of 0.35 nM.2 GRP increases contractility of possum (T. vulpecula) gallbladder strips with an EC50 value of 1.34 nM.3 In vivo, GRP increases gastrin (ED50s = 0.70 and 0.47 nmol/kg2 per hour for peak and integrated values, respectively) and pancreatic polypeptide release (ED50s = 1.2 and 1.01 nmol/kg2 per hour for peak and integrated values, respectively) in conscious cats.4 It also increases acid and pepsin secretion (ED50s = 1.01 and 2.06 nmol/kg2 per hour, respectively) and increases antral stomach motility in conscious cats. GRP (28 μg/kg) reduces independent ad libitum intake of sucrose and milk from bottles by rats but does not affect intraoral intake of either solution from catheters.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McDonald, T.J., Jörnvall, H., Nisson, G., et al. Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem. Biophys. Res. Commun. 90(1), 227-233 (1979).

    2. Preston, S.R., Woodhouse, L.F., Gokhale, J., et al. Characterization of a bombesin/gastrin-releasing peptide receptor on a human gastric-cancer cell line. Int. J. Cancer 57(5), 731-741 (1994).

    3. Carbone, A., Schloithe, A.C., Harvey, J.R., et al. Gastrin-releasing peptide stimulates possum gallbladder contractility in vitro. Peptides 18(7), 1067-1071 (1997).

    4. Vagne, M., Collinet, M., Cuber, J.C., et al. Effect of porcine gastrin releasing peptide on gastric secretion and motility and the release of hormonal peptides in conscious cats. Peptides 8(3), 423-430 (1987).

    5. Rushing, P.A., and Houpt, T.A. Gastrin-releasing peptide suppresses independent but not intraoral intake. Peptides 20(6), 737-741 (1999).