A peptide hormone
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Gastrin I (human)

Item No. 24457

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolylglycyl-L-prolyl-L-tryptophyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-tyrosylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
CAS Number
10047-33-3
Synonyms
  • Gastrin I (1-17) (human)
  • Gastrin Heptadecapeptide I (human)
Molecular Formula
C97H124N20O31S
Formula Weight
2098.2
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
1% NH3 (Aqueous): 1 mg/mlFormic Acid: 1 mg/ml
SMILES
O=C([C@@H]1CCCN1C(CNC([C@@H]2CCC(N2)=O)=O)=O)N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CC3=CC=C(O)C=C3)C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)CCSC)=O)CC5=CNC6=C5C=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CNC8=C7C=CC=C8
InChi Code
InChI=1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1
InChi Key
GKDWRERMBNGKCZ-RNXBIMIWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $319

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    Product Description

    Gastrin I is an endogenous, gastrointestinal peptide hormone that binds to cholecystokinin (CCK) receptors on human gastric leiomyosarcoma cells (IC50 = 0.9 nM) and in guinea pig gallbladder and pancreatic tissue (IC50s = 1.7 and 2.5 μM, respectively).1,2 It increases levels of cytosolic calcium in isolated rabbit stomach parietal cells (EC50 = 11 nM) and stimulates pepsinogen secretion by isolated human peptic cells (ED50 = 30 nM).3,4 Gastrin I increases histidine decarboxylase (HDC) activity ex vivo in fundic stomach mucosa homogenate and increases gastric acid secretion in vivo in rats when administered at a dose of 1 nmol/kg/h.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miller, L.J. Characterization of cholecystokinin receptors on human gastric smooth muscle tumors. Am. J. Physiol. 247(4 Pt 1), G402-G410 (1984).

    2. von Schrenck, T., Moran, T.H., Heinz-Erian, P., et al. Cholecystokinin receptors on gallbladder muscle and pancreatic acinar cells: A comparative study. Am. J. Physiol. 255(4 Pt 1), G512-G521 (1988).

    3. Letari, O., Mennuni, L., Colombo, S., et al. Cytosolic Ca2+ evaluation in rabbit parietal cells: A novel method to screen gastrin receptor antagonists. Eur. J. Pharmacol. 306(1-3), 325-333 (1996).

    4. Lanas, A.I., Anderson, J.W., Uemura, N., et al. Effects of cholinergic, histaminergic, and peptidergic stimulation on pepsinogen secretion by isolated human peptic cells. Scand. J. Gastroenterol. 29(8), 678-683 (1994).

    5. Kawabata, S., Kanayama, S., Shinomura, Y., et al. Effect of cholecystokinin receptor antagonists, MK-329 and L-365,260, on cholecystokinin-induced acid secretion and histidine decarboxylase activity in the rat. Regul. Pept. 35(1), 1-10 (1991).