A hypothalamic neuropeptide hormone
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MCH (human, mouse, rat) (trifluoroacetate salt)

Item No. 24462

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-phenylalanyl-L-α-aspartyl-L-methionyl-L-leucyl-L-arginyl-L-cysteinyl-L-methionyl-L-leucylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-arginyl-L-prolyl-L-cysteinyl-L-tryptophyl-L-glutaminyl-L-valine, cyclic (7→16)-disulfide, trifluoroacetate salt
Synonyms
  • Melanin-Concentrating Hormone
Molecular Formula
C105H160N30O26S4 • XCF3COOH
Formula Weight
2386.8
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C2=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)CCSC)=O)CSSC[C@H](N2)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)=O)CCSC)=O)CC(O)=O)=O)CC6=CC=CC=C6)=O)CC(O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C105H160N30O26S4.C2HF3O2/c1-53(2)42-70-86(144)118-50-80(138)119-64(24-16-36-114-103(108)109)90(148)133-83(55(5)6)100(158)130-73(45-58-28-30-60(136)31-29-58)93(151)124-69(26-18-38-116-105(112)113)101(159)135-39-19-27-78(135)99(157)132-77(98(156)128-74(46-59-49-117-63-23-15-14-22-61(59)63)95(153)121-66(32-33-79(107)137)91(149)134-84(56(7)8)102(160)161)52-165-164-51-76(97(155)123-68(35-41-163-10)88(146)126-70)131-87(145)65(25-17-37-115-104(110)111)120-92(150)71(43-54(3)4)127-89(147)67(34-40-162-9)122-96(154)75(48-82(141)142)129-94(152)72(44-57-20-12-11-13-21-57)125-85(143)62(106)47-81(139)140;3-2(4,5)1(6)7/h11-15,20-23,28-31,49,53-56,62,64-78,83-84,117,136H,16-19,24-27,32-48,50-52,106H2,1-10H3,(H2,107,137)(H,118,144)(H,119,138)(H,120,150)(H,121,153)(H,122,154)(H,123,155)(H,124,151)(H,125,143)(H,126,146)(H,127,147)(H,128,156)(H,129,152)(H,130,158)(H,131,145)(H,132,157)(H,133,148)(H,134,149)(H,139,140)(H,141,142)(H,160,161)(H4,108,109,114)(H4,110,111,115)(H4,112,113,116);(H,6,7)/t62-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,83-,84-;/m0./s1
InChi Key
OXGQGVLSZHKNEA-RHYDOJFISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $416

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    Product Description

    Melanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors.1 It binds to MCH1 and MCH2 receptors (IC50s = 0.17 and 2.9 nM, respectively, for the human receptors) and stimulates calcium accumulation with EC50 values of 28 and 50 nM, respectively, in an aequorin bioluminescence functional assay. MCH also binds to the rat MCH1 receptor (Ki = 0.16 nM in CHO cells), stimulates calcium accumulation (EC50 = 1.79 nM), and inhibits intracellular cAMP accumulation induced by forskolin (Item No. 11018; EC50 = 0.46 nM).2 It binds to mouse MCH receptors on melanoma B16 cells (Ki = 33 nM) and dose-dependently activates the mitogen-activated protein kinase (MAPK) signaling pathway.3 MCH (5 nmol/kg, i.c.v.) increases cumulative food intake in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bednarek, M.A., Tan, C., Hreniuk, D.L., et al. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. The Journal of Biological Chemisty 277(16), 13821-13826 (2002).

    2. Maulon-Feraille, L., Della Zuana, O., Suply, T., et al. Appetite-boosting property of pro-melanin-concentrating hormone131-165 (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance. J. Pharmacol. Exp. Ther. 302(2), 766-773 (2002).

    3. Schlumberger, S.E., Saito, Y., Giller, T., et al. Different structural requirements for melanin-concentrating hormone (MCH) interacting with rat MCH-R1 (SLC-1) and mouse B16 cell MCH-R. J. Recept. Signal Transduct. Res. 23(1), 69-81 (2003).