An NaCT inhibitor
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BI-01383298

Item No. 24482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3,5-dichlorophenyl)sulfonyl]-N-[(4-fluorophenyl)methyl]-4-piperidinecarboxamide
CAS Number
2227549-00-8
Molecular Formula
C19H19Cl2FN2O3S
Formula Weight
445.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 5 mg/ml
SMILES
ClC1=CC(Cl)=CC(S(N2CCC(C(NCC3=CC=C(F)C=C3)=O)CC2)(=O)=O)=C1
InChi Code
InChI=1S/C19H19Cl2FN2O3S/c20-15-9-16(21)11-18(10-15)28(26,27)24-7-5-14(6-8-24)19(25)23-12-13-1-3-17(22)4-2-13/h1-4,9-11,14H,5-8,12H2,(H,23,25)
InChi Key
VUOYAALVGSMUHC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $118

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    25 mg

    $197

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    50 mg

    $303

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    Product Description

    BI-01383298 is an inhibitor of the sodium-coupled citrate transporter (NaCT; IC50 = ~100 nM).1 It irreversibly inhibits sodium-dependent citrate uptake, but not nicotinate, arginine, glutamine, tryptophan, or lactate uptake, in HepG2 cells when used at concentrations ranging from 0.01 to 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Higuchi, K., Kopel, J.J., Sivaprakasam, S., et al. Functional analysis of a species-specific inhibitor selective for human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY). Biochem. J. 477(21), 4149-4165 (2020).