A peptide agonist of NK3
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Neurokinin B (trifluoroacetate salt)

Item No. 24542

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-L-valylglycyl-L-leucyl-L-methioninamide, 2,2,2-trifluoroacetate
Synonyms
  • Neurokinin β
  • Neuromedin K
Molecular Formula
C55H79N13O14S2 • XCF3COOH
Formula Weight
1210.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)C(C)C)=O)CC2=CC=CC=C2)=O)=O)CC(O)=O)[C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCSC)=O)CC3=CNC=N3.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C55H79N13O14S2.C2HF3O2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71;3-2(4,5)1(6)7/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73);(H,6,7)/t35-,36-,37-,38-,39-,40-,41-,42-,46-;/m0./s1
InChi Key
ZQXWSRCHLZXNEZ-SBPCDBINSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

    $120

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    Product Description

    Neurokinin B is a tachykinin peptide agonist of the neurokinin-3 receptor (NK3; Ki = 0.8 nM).1,2 In vitro, neurokinin B dose-dependently induces calcium mobilization in HEK293 cells expressing NK3 (EC50 = 0.5 nM), an effect inhibited by NK3 antagonists. Neurokinin B potentiates electrically-induced contractions in rat vas deferens and increases vasodilation in rat hind paw in a dose-dependent manner.1 In juvenile male rhesus monkeys, neurokinin B (100 µg, i.v.) stimulates luteinizing hormone (LH) release and acts within the hypothalamus, suggesting a role in initiating puberty.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holzer-Petsche, U., Schimek, E., Amann, R., et al. In vivo and in vitro actions of mammalian tachykinins. Naunyn Schmiedebergs Arch. Pharmacol. 330(2), 130-135 (1985).

    2. Sarau, H.M., Griswold, D.E., Potts, W., et al. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J. Pharmacol. Exp. Ther. 281(3), 1303-1311 (1997).

    3. Ramaswamy, S., Seminara, S.B., Ali, B., et al. Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. Endocrinology 151(9), 4494-4503 (2010).