A peptide agonist of the NMB receptor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Neuromedin B (trifluoroacetate salt)

Item No. 24543

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-asparaginyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonylglycyl-L-histidyl-L-phenylalanyl-L-methioninamide, 2,2,2-trifluoroacetate
Synonyms
  • NMB
Molecular Formula
C52H73N15O12S • XCF3COOH
Formula Weight
1132.3
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC(CN[H])=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCSC)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C52H73N15O12S.C2HF3O2/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5;3-2(4,5)1(6)7/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73);(H,6,7)/t28-,29+,35-,36-,37-,38-,39-,40-,44-;/m0./s1
InChi Key
RATZXJUGJPBSDM-XVRGBKBISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $94

    Add
    Product Description

    Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor).1 It displays similar affinity for frog [Phe13]bombesin receptors (Ki = 11 nM) and lower affinities for human gastrin-releasing peptide receptor and bombesin receptor subtype 3 (Kis = 440 and 4,800 nM, respectively). Intrathecal administration of NMB (0.1-1 nmol) induces dose-dependent itching behavior in mice.2 NMB (50 μg, s.c.) reduces serum thyroid stimulating hormone (TSH) by 30% in mice indicating a role in pituitary-thyroid axis function.3 In rodents, NMB is also involved in mediating stress and fear responses, thermoregulation, and can stimulate the contraction of the uterus and gastrointestinal smooth muscle.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ryan, R.R., Katsuno, T., Mantey, S.A., et al. Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. J. Pharmacol. Exp. Ther. 290(3), 1202-1211 (1999).

    2. Sukhtankar, D.D., and Ko, M.C. Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. PLoS One 8(6):e67422, (2013).

    3. Oliveira, K.J., Ortiga-Carvalho, T.M., Cabanelas, A., et al. Disruption of neuromedin B receptor gene results in dysregulation of the pituitary-thyroid axis. J. Mol. Endocrinol. 36(1), 73-80 (2006).

    4. Gonzaelz, N., Moody, T.W., Igarashi, H., et al. Bombesin-related peptides and their receptors: Recent advances in their role in physiology and disease states. Curr. Opin. Endocrinol. Diabetes Obes. 15(1), 58-64 (2008).