An encephalitogenic peptide
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Myelin Basic Protein Peptide (human, bovine, rat) (trifluoroacetate salt)

Item No. 24546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valyl-L-histidyl-L-phenylalanyl-L-phenylalanyl-L-lysyl-L-asparaginyl-L-isoleucyl-L-valyl-L-threonyl-L-prolyl-L-arginyl-L-threonyl-L-proline, trifluoroacetate salt
Synonyms
  • MBP Peptide
Molecular Formula
C74H114N20O17 • XCF3COOH
Formula Weight
1555.8
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@@H](C)O)([H])C(N2CCC[C@H]2C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C74H114N20O17.C2HF3O2/c1-9-41(6)58(70(107)89-57(40(4)5)69(106)92-60(43(8)96)71(108)93-31-19-27-53(93)67(104)84-48(26-18-30-81-74(78)79)62(99)91-59(42(7)95)72(109)94-32-20-28-54(94)73(110)111)90-66(103)52(36-55(76)97)87-61(98)47(25-16-17-29-75)83-63(100)49(33-44-21-12-10-13-22-44)85-64(101)50(34-45-23-14-11-15-24-45)86-65(102)51(35-46-37-80-38-82-46)88-68(105)56(77)39(2)3;3-2(4,5)1(6)7/h10-15,21-24,37-43,47-54,56-60,95-96H,9,16-20,25-36,75,77H2,1-8H3,(H2,76,97)(H,80,82)(H,83,100)(H,84,104)(H,85,101)(H,86,102)(H,87,98)(H,88,105)(H,89,107)(H,90,103)(H,91,99)(H,92,106)(H,110,111)(H4,78,79,81);(H,6,7)/t41-,42+,43+,47-,48-,49-,50-,51-,52-,53-,54-,56-,57-,58-,59-,60-;/m0./s1
InChi Key
GYSGNVKYTDIYFU-XVWGFEIOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $219

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    Product Description

    Myelin Basic Protein Peptide (MBP) is an encephalitogenic peptide and a peptide fragment that corresponds to amino acid residues 221-233 of the human MBP sequence. Active immunization with MBP peptide induces experimental autoimmune encephalomyelitis (EAE) in SJL/J mice and Lewis rats. It induces T cell and microglial activation and MHC class II expression in the spinal cord and decreases latency to paw withdrawal in response to mechanical and thermal stimuli in rats without inducing paralysis.1 Intranasal administration of MBP peptide, alone or in combination with MBP (68-86), prior to immunization with guinea pig MBP (gp-MBP) confers protection against EAE induction in Lewis rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perera, C.J., Lees, J.G., Duffy, S.S., et al. Effects of active immunisation with myelin basic protein and myelin-derived altered peptide ligand on pain hypersensitivity and neuroinflammation. J. Neuroimmunol. 286, 59-70 (2015).

    2. Liu, J.-Q., Bai, X.-F., Shi, F.-D., et al. Inhibition of experimental autoimmune encephalomyelitis in Lewis rats by nasal administration of encephalitogenic MBP peptides: Synergistic effects of MBP 68-86 and 87-99. Int. Immunol. 10(8), 1139-1148 (1998).