A neuropeptide ligand for GPR7 and GPR8
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Neuropeptide W-23 (human) (trifluoroacetate salt)

Item No. 24551

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tryptophyl-L-tyrosyl-L-lysyl-L-histidyl-L-valyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-tyrosyl-L-histidyl-L-threonyl-L-valylglycyl-L-arginyl-L-alanyl-L-alanylglycyl-L-leucyl-L-leucyl-L-methionylglycyl-L-leucine, trifluoroacetate salt
Synonyms
  • NPW23 (human)
Molecular Formula
C119H183N35O28S • XCF3COOH
Formula Weight
2584.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CO)C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCSC)=O)=O)=O)=O)C)=O)C)=O)=O)=O)=O)=O)CC2=CN=CN2)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)C)=O)=O)CC4=CN=CN4)=O)=O)CC5=CC=C(O)C=C5)=O)CC6=CNC7=C6C=CC=C7.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C119H183N35O28S.C2HF3O2/c1-60(2)43-83(106(170)146-84(44-61(3)4)107(171)143-82(37-42-183-15)102(166)132-55-94(161)141-89(117(181)182)45-62(5)6)140-93(160)54-131-98(162)65(11)136-99(163)66(12)137-103(167)79(26-20-39-128-118(122)123)139-92(159)56-133-113(177)95(63(7)8)152-115(179)97(68(14)156)153-111(175)88(50-73-53-127-59-135-73)149-109(173)86(47-70-31-35-75(158)36-32-70)147-105(169)81(27-21-40-129-119(124)125)144-112(176)91-28-22-41-154(91)116(180)90(57-155)150-100(164)67(13)138-114(178)96(64(9)10)151-110(174)87(49-72-52-126-58-134-72)148-104(168)80(25-18-19-38-120)142-108(172)85(46-69-29-33-74(157)34-30-69)145-101(165)77(121)48-71-51-130-78-24-17-16-23-76(71)78;3-2(4,5)1(6)7/h16-17,23-24,29-36,51-53,58-68,77,79-91,95-97,130,155-158H,18-22,25-28,37-50,54-57,120-121H2,1-15H3,(H,126,134)(H,127,135)(H,131,162)(H,132,166)(H,133,177)(H,136,163)(H,137,167)(H,138,178)(H,139,159)(H,140,160)(H,141,161)(H,142,172)(H,143,171)(H,144,176)(H,145,165)(H,146,170)(H,147,169)(H,148,168)(H,149,173)(H,150,164)(H,151,174)(H,152,179)(H,153,175)(H,181,182)(H4,122,123,128)(H4,124,125,129);(H,6,7)/t65-,66-,67-,68+,77-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,95-,96-,97-;/m0./s1
InChi Key
ALTFECKKLYPFNK-MRWXLVHASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Neuropeptide W-23 (NPW23) is an endogenous neuropeptide ligand for the orphan G protein-coupled receptors GPR7 and GPR8 (Kis = 31.8 and 20.7 pM, respectively).1 It inhibits forskolin-induced cAMP accumulation in CHO cells expressing human GPR7 and GPR8 with IC50 values of 0.025 and 0.178 nM, respectively. NPW23 (3 nmol) stimulates prolactin release in rats but has no effect on other pituitary hormones. NPW23 attenuates mechanical allodynia, but not thermal hyperalgesia, induced by carrageenan injection in rat paw in a dose-dependent manner.2 It also decreases food intake and weight gain as well as increases body temperature and thermogenesis in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimomura, Y., Harada, M., Goto, M., et al. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. The Journal of Biological Chemisty 277(39), 35826-35832 (2002).

    2. Yamamoto, T., Saito, O., Shono, K., et al. Anti-hyperalgesic effects of intrathecally administered neuropeptide W-23, and neuropeptide B, in tests of inflammatory pain in rats. Brain Res. 1045(1-2), 97-106 (2005).

    3. Naso, T., Shousha, S., and El-Kirdasy, A. Central neuropeptide W has anorexigenic effect in rats. J. Anim. Physiol. Anim. Nutr. (Berl.) 98(2), 228-234 (2014).