An NPY receptor agonist
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Pancreatic Polypeptide (human) (trifluoroacetate salt)

Item No. 24555

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-prolyl-L-valyl-L-tyrosyl-L-prolylglycyl-L-α-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-alanyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-leucyl-L-threonyl-L-arginyl-L-prolyl-L-arginyl-L-tyrosinamide, trifluoroacetate salt
CAS Number
75976-10-2
Molecular Formula
C185H287N53O54S2
Formula Weight
4181.8
Purity
≥95%
Formulation
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC([C@@]([C@@H](C)O)([H])NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@@H]2CCCN2C([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC(CNC([C@@H]3CCCN3C([C@@H](NC([C@H](C(C)C)NC([C@@H]4CCCN4C([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H]5CCCN5C([C@@H](N[H])C)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)CC(O)=O)=O)=O)C)=O)=O)=O)=O)=O)CCSC)=O)C)=O)=O)CC7=CC=C(O)C=C7)=O)C)=O)C)=O)CC(O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O
InChi Code
InChI=1S/C185H287N53O54S2/c1-20-92(10)144(175(286)228-125(84-137(190)248)164(275)215-115(64-75-294-19)159(270)222-121(78-90(6)7)167(278)232-145(98(16)239)176(287)219-116(33-24-68-203-185(198)199)178(289)236-71-27-36-131(236)170(281)216-110(32-23-67-202-184(196)197)154(265)220-118(147(191)258)79-100-39-47-104(241)48-40-100)231-168(279)123(81-102-43-51-106(243)52-44-102)225-155(266)109(31-22-66-201-183(194)195)211-153(264)108(30-21-65-200-182(192)193)212-162(273)119(76-88(2)3)223-166(277)127(86-142(256)257)221-150(261)95(13)205-148(259)94(12)207-160(271)122(80-101-41-49-105(242)50-42-101)224-158(269)111(55-59-134(187)245)210-149(260)96(14)206-152(263)114(63-74-293-18)214-156(267)112(56-60-135(188)246)213-157(268)113(57-61-139(250)251)217-171(282)132-37-29-73-238(132)181(292)146(99(17)240)233-151(262)97(15)208-161(272)124(83-136(189)247)226-165(276)126(85-141(254)255)209-138(249)87-204-169(280)129-34-25-70-235(129)180(291)128(82-103-45-53-107(244)54-46-103)229-174(285)143(91(8)9)230-173(284)133-38-28-72-237(133)179(290)117(58-62-140(252)253)218-163(274)120(77-89(4)5)227-172(283)130-35-26-69-234(130)177(288)93(11)186/h39-54,88-99,108-133,143-146,239-244H,20-38,55-87,186H2,1-19H3,(H2,187,245)(H2,188,246)(H2,189,247)(H2,190,248)(H2,191,258)(H,204,280)(H,205,259)(H,206,263)(H,207,271)(H,208,272)(H,209,249)(H,210,260)(H,211,264)(H,212,273)(H,213,268)(H,214,267)(H,215,275)(H,216,281)(H,217,282)(H,218,274)(H,219,287)(H,220,265)(H,221,261)(H,222,270)(H,223,277)(H,224,269)(H,225,266)(H,226,276)(H,227,283)(H,228,286)(H,229,285)(H,230,284)(H,231,279)(H,232,278)(H,233,262)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,192,193,200)(H4,194,195,201)(H4,196,197,202)(H4,198,199,203)/t92-,93-,94-,95-,96-,97-,98+,99+,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,143-,144-,145-,146-/m0/s1
InChi Key
HFDKKNHCYWNNNQ-YOGANYHLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $336

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    Product Description

    Pancreatic polypeptide is an agonist of neuropeptide Y (NPY) receptors that reduces forskolin-induced cAMP accumulation in L-M(TK-) cells recombinantly expressing human and rat Y4 receptors (EC50s = 87.1 and 36.3 pM, respectively).1 It binds to Y1 and Y5 receptors with Ki values of 19 and 3.9 nM, respectively, for human and 50 and 2.4 nM, respectively, for rhesus monkey receptors.2 Pancreatic polypeptide also binds to rabbit Y1, Y2, Y4, and Y5 receptors (Kis = 0.39, 0.087, 0.79, and 0.24 nM, respectively).3 It induces contractile responses in isolated rat colon with EC50 values of 1.6 and 0.7 nM for ascending and descending colon segments, respectively.4 In vivo, pancreatic polypeptide (0.7-7 nmol, i.c.v.) increases food intake in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Walker, M.W., Smith, K.E., Bard, J., et al. A structure-activity analysis of the cloned rat and human Y4 receptors for pancreatic polypeptide. Peptides 18(4), 609-612 (1997).

    2. Gehlert, D.R., Yang, P., George, C., et al. Cloning and characterization of Rhesus monkey neuropeptide Y receptor subtypes. Peptides 22(3), 343-350 (2001).

    3. Umeda, T., Kanatani, A., and Iwaasa, H. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. Peptides 30(8), 1441-1447 (2009).

    4. Pheng, L.-H., Perron, A., Quirion, R., et al. Neuropeptide Y-induced contraction is mediated by neuropeptide Y Y2 and Y4 receptors in the rat colon. Eur. J. Pharmacol. 374(1), 85-91 (1999).

    5. Haynes, A.C., Arch, J.R.S., Wilson, S., et al. Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: A role for the Y5 receptor? Regul. Pept. 75-76, 355-361 (1998).