A prion peptide
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Prion Protein (106-126) (trifluoroacetate salt)

Item No. 24556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-threonyl-L-asparaginyl-L-methionyl-L-lysyl-L-histidyl-L-methionyl-L-alanylglycyl-L-alanyl-L-alanyl-L-alanyl-L-alanylglycyl-L-alanyl-L-valyl-L-valylglycylglycyl-L-leucyl-glycine, trifluoroacetate salt
Synonyms
  • PrP
Molecular Formula
C80H138N26O24S2 • XCF3COOH
Formula Weight
1912.2
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](CC(C)C)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)CCSC)=O)CC1=CN=CN1)=O)=O)CCSC)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C80H138N26O24S2.C2HF3O2/c1-38(2)28-53(72(122)90-36-61(113)114)98-60(112)33-86-57(109)32-89-78(128)62(39(3)4)105-79(129)63(40(5)6)104-70(120)44(10)93-59(111)35-87-65(115)41(7)94-68(118)45(11)96-69(119)46(12)95-67(117)43(9)92-58(110)34-88-66(116)42(8)97-73(123)51(22-26-131-14)100-76(126)54(29-48-31-85-37-91-48)102-74(124)50(21-17-19-25-82)99-75(125)52(23-27-132-15)101-77(127)55(30-56(84)108)103-80(130)64(47(13)107)106-71(121)49(83)20-16-18-24-81;3-2(4,5)1(6)7/h31,37-47,49-55,62-64,107H,16-30,32-36,81-83H2,1-15H3,(H2,84,108)(H,85,91)(H,86,109)(H,87,115)(H,88,116)(H,89,128)(H,90,122)(H,92,110)(H,93,111)(H,94,118)(H,95,117)(H,96,119)(H,97,123)(H,98,112)(H,99,125)(H,100,126)(H,101,127)(H,102,124)(H,103,130)(H,104,120)(H,105,129)(H,106,121)(H,113,114);(H,6,7)/t41-,42-,43-,44-,45-,46-,47+,49-,50-,51-,52-,53-,54-,55-,62-,63-,64-;/m0./s1
InChi Key
LYYMRJVEXNBJPY-CSJRDFOLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $422

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    Product Description

    Prion Protein (106-126) is a peptide fragment of the cellular prion protein PrPc.1 It forms fibrils that are organized into β-strands, a behavior characteristic of amyloids. It is toxic to primary rat hippocampal neurons at a concentration of 80 μM following incubation for 10 days and induces DNA fragmentation and apoptosis. Prion Protein (106-126) (25 μM) activates ERK1 and 2, p38, and JNK1 and 2 kinases, induces apoptosis, increases NADPH oxidase-dependent production of reactive oxygen species (ROS), and decreases glutathione (GSH) levels in 1C115-HT serotonergic and 1C11NE noradrenergic differentiated neuronal cells.2 It forms channels in lipid bilayer membranes that are freely permeable to calcium, sodium, potassium, lithium, rubidium, cesium, and chloride ions at a concentration of 20 μM, and channel formation is significantly enhanced by aging and low pH.3 In vivo, intraocular injection of prion protein (106-126) (1 mM) increases the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) positive nuclei in mice 4 days post injection.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Forloni, G., Angeretti, N., Chiesa, R., et al. Neurotoxicity of a prion protein fragment. Nature 362(6420), 543-546 (1993).

    2. Pietri, M., Caprini, A., Mouillet-Richard, S., et al. Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. The Journal of Biological Chemisty 281(38), 28470-28479 (2006).

    3. Lin, M.-C., Mirzabekov, T., and Kagan, B.L. Channel formation by a neurotoxic prion protein fragment. The Journal of Biological Chemisty 272(1), 44-47 (1997).

    4. Bergström, A.-L., Cordes, H., Zsurger, N., et al. Amidation and structure relaxation abolish the neurotoxicity of the prion peptide PrP106-126 in vivo and in vitro. The Journal of Biological Chemisty 280(24), 23114-23121 (2005).