A caspase-1 and ACE2 fluorogenic substrate
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Alternative(s)
27137Z-YVAD-AFC (trifluoroacetate salt)
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Mca-YVADAP-K(Dnp)-OH (trifluoroacetate salt)

Item No. 24562

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-tyrosyl-L-valyl-L-alanyl-L-α-aspartyl-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-L-lysine, trifluoroacetate salt
Synonyms
  • Caspase-1 Fluorogenic Substrate V
  • Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(DNP)-OH
  • Mca-YVADAP-Lys(Dnp)-OH
  • (7-Methoxycoumarin-4-yl)acetyl-YVADAPK(2,4-dinitrophenyl)-OH
Molecular Formula
C53H64N10O19 • XCF3COOH
Formula Weight
1145.1
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
COC1=CC=C(C(CC(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N3CCC[C@H]3C(N[C@@H](CCCCNC4=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=CC(O5)=O)C5=C1.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C53H64N10O19.C2HF3O2/c1-27(2)46(60-49(71)38(21-30-11-14-33(64)15-12-30)57-43(65)22-31-23-45(68)82-42-25-34(81-5)16-17-35(31)42)51(73)55-28(3)47(69)59-39(26-44(66)67)48(70)56-29(4)52(74)61-20-8-10-40(61)50(72)58-37(53(75)76)9-6-7-19-54-36-18-13-32(62(77)78)24-41(36)63(79)80;3-2(4,5)1(6)7/h11-18,23-25,27-29,37-40,46,54,64H,6-10,19-22,26H2,1-5H3,(H,55,73)(H,56,70)(H,57,65)(H,58,72)(H,59,69)(H,60,71)(H,66,67)(H,75,76);(H,6,7)/t28-,29-,37-,38-,39-,40-,46-;/m0./s1
InChi Key
IDHHNDRKPWTJSE-VXJHEXFUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $174

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    Product Description

    Mca-YVADAP-K(Dnp)-OH is a substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2).1,2 Upon cleavage by caspase-1 or ACE2, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify enzyme activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vickers, C., Hales, P., Kaushik, V., et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. The Journal of Biological Chemisty 277(17), 14838-14843 (2002).

    2. Enari, M., Talanian, R.V., Wong, W.W., et al. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380(6576), 723-726 (1996).