A caspase-3 fluorogenic substrate
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Z-DEVD-AFC

Item No. 24564

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5S,8S,11S,14S)-8-(2-carboxyethyl)-5-(carboxymethyl)-11-isopropyl-3,6,9,12-tetraoxo-14-((2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)carbamoyl)-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid
CAS Number
1135416-11-3
Synonyms
  • Caspase-3 Fluorogenic Substrate IV
Molecular Formula
C36H38F3N5O14
Formula Weight
821.7
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(NC1=CC=C(C(C(F)(F)F)=CC(O2)=O)C2=C1)=O)=O)=O)[C@H](CC(O)=O)NC(OCC3=CC=CC=C3)=O
InChi Code
InChI=1S/C36H38F3N5O14/c1-17(2)30(34(55)42-23(14-27(47)48)32(53)40-19-8-9-20-21(36(37,38)39)13-29(51)58-25(20)12-19)44-31(52)22(10-11-26(45)46)41-33(54)24(15-28(49)50)43-35(56)57-16-18-6-4-3-5-7-18/h3-9,12-13,17,22-24,30H,10-11,14-16H2,1-2H3,(H,40,53)(H,41,54)(H,42,55)(H,43,56)(H,44,52)(H,45,46)(H,47,48)(H,49,50)/t22-,23-,24-,30-/m0/s1
InChi Key
JEPURZRNABGOCW-CQUCHYGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $128

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    Product Description

    Z-DEVD-AFC is a fluorogenic substrate for caspase-3.1 Upon cleavage by caspase-3, 7-amino-7-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify caspase-3 activity. AFC displays excitation/emission maxima of 400/505 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Inayat-Hussain, S.H. Processing/activation of CPP32-like proteases is involved in transforming growth factor β1-induced apoptosis in rat hepatocytes. Hepatology 25(6), 1516-1526 (1997).