A caspase-3 fluorogenic substrate
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Mca-VDQMDGW-K(Dnp)-NH2 (ammonium salt)

Item No. 24565

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,6S,9S,12S,18S,21S)-18-((1H-indol-3-yl)methyl)-6-(3-amino-3-oxopropyl)-21-carbamoyl-12-(carboxymethyl)-25-((2,4-dinitrophenyl)amino)-3-((S)-2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)-3-methylbutanamido)-9-(2-(methylthio)ethyl)-4,7,10,13,16,19-hexaoxo-5,8,11,14,17,20-hexaazapentacosanoic acid, ammonium salt
Synonyms
  • Caspase-3 Fluorogenic Substrate V
Molecular Formula
C60H74N14O21S • XNH3
Formula Weight
1359.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
NC([C@@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CNC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC(CC3=CC(OC4=C3C=CC(OC)=C4)=O)=O)C(C)C)=O)=O)CCC(N)=O)=O)=O)=O)=O)=O)CCCCNC5=CC=C([N+]([O-])=O)C=C5[N+]([O-])=O)=O.N
InChi Code
InChI=1S/C60H74N14O21S.H3N/c1-30(2)53(72-48(76)22-31-23-52(82)95-46-25-34(94-3)13-14-36(31)46)60(89)71-44(27-51(80)81)59(88)68-40(16-17-47(61)75)56(85)69-41(18-20-96-4)57(86)70-43(26-50(78)79)55(84)65-29-49(77)66-42(21-32-28-64-37-10-6-5-9-35(32)37)58(87)67-39(54(62)83)11-7-8-19-63-38-15-12-33(73(90)91)24-45(38)74(92)93;/h5-6,9-10,12-15,23-25,28,30,39-44,53,63-64H,7-8,11,16-22,26-27,29H2,1-4H3,(H2,61,75)(H2,62,83)(H,65,84)(H,66,77)(H,67,87)(H,68,88)(H,69,85)(H,70,86)(H,71,89)(H,72,76)(H,78,79)(H,80,81);1H3/t39-,40-,41-,42-,43-,44-,53-;/m0./s1
InChi Key
VHJIOOCCKGODAJ-SKVYSOQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $141

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    1 mg

    $268

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    Product Description

    Mca-VDQMDGW-K(Dnp)-NH2 is a substrate for caspase-3.1 Upon cleavage by caspase-3, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify caspase-3 activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Snyder, D.S., and Small, P.L. Uptake and cellular actions of mycolactone, a virulence determinant for Mycobacterium ulcerans. Microb. Pathog. 34(2), 91-101 (2003).