An antimicrobial peptide
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Defensin HNP-2 (human) (trifluoroacetate salt)

Item No. 24571

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cysteinyl-L-isoleucyl-L-alanylglycyl-L-α-glutamyl-L-arginyl-L-arginyl-L-tyrosylglycyl-L-threonyl-L-cysteinyl-L-isoleucyl-L-tyrosyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-phenylalanyl-L-cysteinyl-L-cysteine cyclic (1→29),(3→18),(8→28)-tris(disulfide), trifluoroacetate salt
Synonyms
  • DEFA2 Protein
  • α-Defensin 2
  • Human Neutrophil Peptide 2
  • Neutrophil Defensin 2
Molecular Formula
C147H217N43O37S6 • XCF3COOH
Formula Weight
3371.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C2=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)C)=O)=O)CSSC[C@H](N4)C5=O)=O)C)=O)=O)=O)=O)CSSC[C@H](N2)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C4=O)CC6=CC=CC=C6)=O)C)=O)CC7=CNC8=C7C=CC=C8)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O)=O)=O)CC%10=CC=C(O)C=C%10)=O)CSSC[C@H](N5)C(O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C147H217N43O37S6.C2HF3O2/c1-13-73(6)114-139(222)168-76(9)118(201)163-63-110(196)170-96(48-50-113(199)200)127(210)172-92(31-22-52-159-145(152)153)125(208)171-93(32-23-53-160-146(154)155)126(209)178-98(58-81-35-41-85(192)42-36-81)123(206)165-65-112(198)186-117(79(12)191)141(224)184-106-70-232-229-67-103-134(217)173-94(33-24-54-161-147(156)157)128(211)189-116(75(8)15-3)142(225)190-55-25-34-108(190)138(221)167-78(11)120(203)181-105(136(219)187-114)69-231-230-68-104(135(218)185-107(143(226)227)71-233-228-66-89(148)121(204)176-100(133(216)182-103)59-82-37-43-86(193)44-38-82)183-132(215)99(57-80-26-17-16-18-27-80)175-119(202)77(10)166-129(212)102(61-84-62-162-90-29-20-19-28-88(84)90)179-130(213)97(56-72(4)5)177-124(207)91(30-21-51-158-144(150)151)169-111(197)64-164-122(205)95(47-49-109(149)195)174-131(214)101(60-83-39-45-87(194)46-40-83)180-140(223)115(74(7)14-2)188-137(106)220;3-2(4,5)1(6)7/h16-20,26-29,35-46,62,72-79,89,91-108,114-117,162,191-194H,13-15,21-25,30-34,47-61,63-71,148H2,1-12H3,(H2,149,195)(H,163,201)(H,164,205)(H,165,206)(H,166,212)(H,167,221)(H,168,222)(H,169,197)(H,170,196)(H,171,208)(H,172,210)(H,173,217)(H,174,214)(H,175,202)(H,176,204)(H,177,207)(H,178,209)(H,179,213)(H,180,223)(H,181,203)(H,182,216)(H,183,215)(H,184,224)(H,185,218)(H,186,198)(H,187,219)(H,188,220)(H,189,211)(H,199,200)(H,226,227)(H4,150,151,158)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161);(H,6,7)/t73-,74-,75-,76-,77-,78-,79+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,114-,115-,116-,117-;/m0./s1
InChi Key
PLDZPWOITNALOZ-QEXVJSNTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Defensin HNP-2 is a peptide with antimicrobial properties that is secreted by human polymorphonuclear leukocytes (PMNs).1 It induces 26.2 and 43.5% lysis of mammalian cells at concentrations of 25 and 100 μg/ml, respectively.2 It also completely inhibits secretion of the exotoxin superantigen TSS toxin-1 (TSST-1) from S. aureus at a concentration of 5 ng/ml and inhibits infection of McCoy cells by C. trachomatis elementary bodies (EBs).3,4 Defensin HNP-2 binds to recombinant HIV-1 envelope glycoprotein gp120 and human CD4 (Kds = 8 and 15.8 nM, respectively).5 It also induces permeabilization of large unilamellar vesicles (LUVs) formed from 1-palmitoyl-2-oleoyl-sn-glycero-3-PG (POPG; Item No. 15105).6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lehrer, R.I. Primate defensins. Nat. Rev. Microbiol. 2(9), 727-738 (2004).

    2. Lichtenstein, A., Ganz, T., Selsted, M.E., et al. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood 68(6), 1407-1410 (1986).

    3. Merriman, J.A., Nemeth, K.A., and Schlievert, P.M. Novel antimicrobial peptides that inhibit gram positive bacterial exotoxin synthesis. PLoS One 9(4), (2014).

    4. Yasin, B., Harwig, S.S.L., Lehrer, R.I., et al. Susceptibility of Chlamydia trachomatis to protegrins and defensins. Infect. Immun. 64(3), 709-713 (1996).

    5. Wang, W., Owen, S.M., Rudolph, D.L., et al. Activity of ɑ- and θ-defensins against primary isolates of HIV-1. J. Immunol. 173(1), 515-520 (2004).

    6. Wimley, W.C., Selsted, M.E., and White, S.H. Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores. Protein Sci. 3(9), 1362-1373 (1994).