An antimicrobial peptide
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Defensin HNP-3 (human) (trifluoroacetate salt)

Item No. 24575

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cysteinyl-L-isoleucyl-L-alanylglycyl-L-α-glutamyl-L-arginyl-L-arginyl-L-tyrosylglycyl-L-threonyl-L-cysteinyl-L-isoleucyl-L-tyrosyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-tryptophyl-L-alanyl-L-phenylalanyl-L-cysteinyl-L-cysteine, cyclic (2→30),(4→19),(9→29)-tris(disulfide), trifluoroacetate salt
Synonyms
  • DEFA3 Protein
  • α-Defensin 3
  • Human Neutrophil Peptide 3
  • Neutrophil Defensin
Molecular Formula
C151H222N44O40S6 • XCF3COOH
Formula Weight
3486.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C2=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)C)=O)=O)CSSC[C@H](N4)C5=O)=O)C)=O)=O)=O)=O)CSSC[C@H](N2)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C4=O)CC6=CC=CC=C6)=O)C)=O)CC7=CNC8=C7C=CC=C8)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O)=O)=O)CC%10=CC=C(O)C=C%10)=O)CSSC[C@H](N5)C(O)=O)=O)CC(O)=O.FC(C(O)=O)(F)F
InChi Code
InChI=1S/C151H222N44O40S6.C2HF3O2/c1-13-74(6)117-143(230)172-77(9)121(208)167-64-112(201)174-97(48-50-115(204)205)130(217)176-93(31-22-52-163-149(156)157)128(215)175-94(32-23-53-164-150(158)159)129(216)181-99(58-82-35-41-86(197)42-36-82)126(213)169-66-114(203)191-120(80(12)196)145(232)189-108-71-239-236-68-105-137(224)177-95(33-24-54-165-151(160)161)131(218)194-119(76(8)15-3)146(233)195-55-25-34-110(195)142(229)171-79(11)123(210)185-107(140(227)192-117)70-238-237-69-106(139(226)190-109(147(234)235)72-241-240-67-104(186-124(211)90(152)62-116(206)207)138(225)182-101(136(223)187-105)59-83-37-43-87(198)44-38-83)188-135(222)100(57-81-26-17-16-18-27-81)179-122(209)78(10)170-132(219)103(61-85-63-166-91-29-20-19-28-89(85)91)183-133(220)98(56-73(4)5)180-127(214)92(30-21-51-162-148(154)155)173-113(202)65-168-125(212)96(47-49-111(153)200)178-134(221)102(60-84-39-45-88(199)46-40-84)184-144(231)118(75(7)14-2)193-141(108)228;3-2(4,5)1(6)7/h16-20,26-29,35-46,63,73-80,90,92-110,117-120,166,196-199H,13-15,21-25,30-34,47-62,64-72,152H2,1-12H3,(H2,153,200)(H,167,208)(H,168,212)(H,169,213)(H,170,219)(H,171,229)(H,172,230)(H,173,202)(H,174,201)(H,175,215)(H,176,217)(H,177,224)(H,178,221)(H,179,209)(H,180,214)(H,181,216)(H,182,225)(H,183,220)(H,184,231)(H,185,210)(H,186,211)(H,187,223)(H,188,222)(H,189,232)(H,190,226)(H,191,203)(H,192,227)(H,193,228)(H,194,218)(H,204,205)(H,206,207)(H,234,235)(H4,154,155,162)(H4,156,157,163)(H4,158,159,164)(H4,160,161,165);(H,6,7)/t74-,75-,76-,77-,78-,79-,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,117-,118-,119-,120-;/m0./s1
InChi Key
VYPSMNJGIMMDIB-VQNLNIFFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Neutrophil Biology Wall Poster

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    Product Description

    Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties.1 It induces lysis of mammalian cells when used at a concentration of 25 μg/mL.2 It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM).3,4 HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively).5 It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd = 55.7 nM) and inhibits focus formation in Madin-Darby canine kidney (MDCK) cells infected with influenza A virus (IAV).6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lehrer, R.I. Primate defensins. Nat. Rev. Microbiol. 2(9), 727-738 (2004).

    2. Lichtenstein, A., Ganz, T., Selsted, M.E., et al. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood 68(6), 1407-1410 (1986).

    3. Miyoshi, S.-i., Koyama, K., Mizuno, T., et al. Defensive effects of human antimicrobial peptide α-defensins against Enterococcus faecalis. J. Health Sci. 56(5), 618-622 (2010).

    4. Wang, H., Dong, B., and Lou, L. HNP-3 enhanced the antimicrobial activity of CIP by promoting ATP efflux from P. aeruginosa cells. Mol. Biol. Rep. 38(4), 2673-2678 (2011).

    5. Wang, W., Owen, S.M., Rudolph, D.L., et al. Activity of ɑ- and θ-defensins against primary isolates of HIV-1. J. Immunol. 173(1), 515-520 (2004).

    6. Doss, M., White, M.R., Tecle, T., et al. Interactions of α-, β-, and θ-defensins with influenza A virus and surfactant protein D. J. Immunol. 182(12), 7878-7887 (2009).