An antimicrobial peptide
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β-Defensin-2 (human) (trifluoroacetate salt)

Item No. 24577

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-isoleucylglycyl-L-α-aspartyl-L-prolyl-L-valyl-L-threonyl-L-cysteinyl-L-leucyl-L-lysyl-L-serylglycyl-L-alanyl-L-isoleucyl-L-cysteinyl-L-histidyl-L-prolyl-L-valyl-L-phenylalanyl-L-cysteinyl-L-prolyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-glutaminyl-L-isoleucylglycyl-L-threonyl-L-cysteinylglycyl-L-leucyl-L-prolylglycyl-L-threonyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-lysyl-L-proline, cyclic (8→37),(15→30),(20→38)-tris(disulfide), trifluoroacetate salt
Synonyms
  • hBD-2
Molecular Formula
C188H305N55O50S6• XCF3COOH
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]NCC(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@]([C@@H](C)O)([H])C4=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)CSSC[C@H](N6)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N7CCC[C@H]7C(O)=O)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)CC9=CN=CN9)=O)CSSC[C@H](N4)C(NCC(N[C@@H](CC(C)C)C(N%10CCC[C@H]%10C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C%11=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)CSSC[C@H](N%11)C6=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C188H305N55O50S6.C2HF3O2/c1-19-99(12)146(231-137(250)80-194)173(279)206-84-140(253)211-123(79-143(256)257)184(290)241-71-40-54-134(241)172(278)235-145(98(10)11)176(282)238-151(105(18)247)180(286)229-128-91-297-295-90-127-168(274)226-126(165(271)215-111(45-26-31-63-190)157(263)219-117(48-29-34-66-193)181(287)243-73-41-55-135(243)186(292)293)89-298-299-93-130-185(291)242-72-38-52-132(242)170(276)217-115(50-36-68-202-188(198)199)156(262)212-114(49-35-67-201-187(196)197)158(264)221-119(77-107-56-58-109(248)59-57-107)163(269)214-110(44-25-30-62-189)155(261)216-116(60-61-136(195)249)161(267)237-147(100(13)20-2)174(280)207-86-142(255)233-150(104(17)246)179(285)227-125(154(260)204-83-139(252)210-121(75-96(6)7)182(288)239-69-37-51-131(239)169(275)205-85-141(254)232-149(103(16)245)178(284)218-113(160(266)225-127)47-28-33-65-192)88-294-296-92-129(167(273)223-122(78-108-81-200-94-208-108)183(289)240-70-39-53-133(240)171(277)234-144(97(8)9)175(281)222-120(164(270)230-130)76-106-42-23-22-24-43-106)228-177(283)148(101(14)21-3)236-152(258)102(15)209-138(251)82-203-153(259)124(87-244)224-159(265)112(46-27-32-64-191)213-162(268)118(74-95(4)5)220-166(128)272;3-2(4,5)1(6)7/h22-24,42-43,56-59,81,94-105,110-135,144-151,244-248H,19-21,25-41,44-55,60-80,82-93,189-194H2,1-18H3,(H2,195,249)(H,200,208)(H,203,259)(H,204,260)(H,205,275)(H,206,279)(H,207,280)(H,209,251)(H,210,252)(H,211,253)(H,212,262)(H,213,268)(H,214,269)(H,215,271)(H,216,261)(H,217,276)(H,218,284)(H,219,263)(H,220,272)(H,221,264)(H,222,281)(H,223,273)(H,224,265)(H,225,266)(H,226,274)(H,227,285)(H,228,283)(H,229,286)(H,230,270)(H,231,250)(H,232,254)(H,233,255)(H,234,277)(H,235,278)(H,236,258)(H,237,267)(H,238,282)(H,256,257)(H,292,293)(H4,196,197,201)(H4,198,199,202);(H,6,7)/t99-,100-,101-,102-,103+,104+,105+,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,144-,145-,146-,147-,148-,149-,150-,151-;/m0./s1
InChi Key
JJDUNZFWULIMFT-YIYXCTSTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 µg

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    Product Description

    β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1 It inhibits the growth of periodontopathogenic and cariogenic bacteria, including P. gingivalis and S. salivarius.2 β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3 It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-2 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.4 Expression of β-defensin-2 is increased in psoriatic skin and chronic wounds.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lehrer, R.I. Primate defensins. Nat. Rev. Microbiol. 2(9), 727-738 (2004).

    2. Ouhara, K., Komatsuzawa, H., Yamada, S., et al. Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cells. J. Antimicrob. Chemother. 55(6), 888-896 (2005).

    3. Niyonsaba, F., Ushio, H., Nakano, N., et al. Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J. Invest. Dermatol. 127(3), 594-604 (2007).

    4. Niyonsaba, F., Ushio, H., Hara, M., et al. Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J. Immunol. 184(7), 3526-3534 (2010).

    5. Huh, W.-K., Oono, T., Shirafuji, Y., et al. Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin. J. Mol. Med. (Berl.) 80(10), 678-684 (2002).

    6. Butmarc, J., Yufit, T., Carson, P., et al. Human β-defensin-2 expression is increased in chronic wounds. Wound Repair Regen. 12(4), 439-443 (2004).